2503-26-6
2503-26-6 結(jié)構(gòu)式
基本信息
黑僵菌素 B
綠僵菌素B, 來源于綠僵菌屬
Destruxin B from Metarhizium anisopliae
Destruxin B, from Metarrhizium anisopliae
Destruxin B, 97.5%, from Metarrhizium anisopliae
N-[N-[(R)-2-Hydroxy-4-methyl-1-oxopentyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone
Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl]
N-[N-[(2R)-1-Oxo-2-hydroxy-4-methylpentyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-N6690 | 綠僵菌素B, 來源于綠僵菌屬 Destruxin B | 2503-26-6 | 1mg | 7800元 |
| 2023/10/26 | HY-N6690 | 綠僵菌素B, 來源于綠僵菌屬 Destruxin B | 2503-26-6 | 5mg | 27500元 |
常見問題列表
|
Bcl-2
|
Caspase-3
|
Destruxin B (1-30 μM; 48 hours) inhibits cell proliferation of H1299 cells and A549 cells, with IC
50
s of 4.1?μM and 4.9?μM, respectively.
Activation of mitochondria-dependent caspase cascade plays an important role in Destruxin B (1-30 μM; 48 hours) induced apoptotic cell death in A549 cells.
Destruxin B (1.25-20.00 μM; 72 hours) treatment significantly inhibits HT-29 human colorectal cancer cells viability in time- and dose-dependent manners.
Destruxin B (10 or 20?μM; 12 and 24 hours) treatment markedly increases levels of the proapoptotic protein PUMA and reduces levels of antiapoptotic proteins Mcl-1 of A549 cells in a concentration- and time-dependent manner .
Cell Proliferation Assay
| Cell Line: | H1299 cells |
| Concentration: | 1, 5, 10, 20, 30?μM |
| Incubation Time: | 48? hours |
| Result: | Inhibited H1299 cells proliferation of H1299 cells with an IC 50 of 4.1?μM. |
Apoptosis Analysis
| Cell Line: | Lung adenocarcinoma A549 cells |
| Concentration: | 1, 5, 10, 20, 30?μM |
| Incubation Time: | 48? hours |
| Result: | Induces caspase-dependent Lung adenocarcinoma A549 cells death. |
Cell Viability Assay
| Cell Line: | HT-29 human colorectal cancer cells |
| Concentration: | 1.25, 2.50, 5.00, 10.00 and 20.00 μM |
| Incubation Time: | 72 hours |
| Result: | The IC 50 s at 24 h, 48 h and 72h were determined as 14.97, 2.00 and 0.67 μM, respectively. |
Western Blot Analysis
| Cell Line: | A549 cells |
| Concentration: | 10 or 20?μM |
| Incubation Time: | 12 and 24? hours |
| Result: | Regulates Mcl-1 and PUMA. |
Destruxin B (DB) ( injection; 0.6-15 mg/kg/day for 6 weeks) attenuates the tumor growth in time- and dose-dependent manners.
| Animal Model: | Athymic female nude mice (BALB/cAnN.Cg-Foxn1nu/CrlNarl), approximately 4-5 weeks old on arrival |
| Dosage: | Low dose (0.6 mg/kg), medium dose (3 mg/kg), high dose (15 mg/kg) |
| Administration: | Injection; daily; for 6 weeks |
| Result: | Low dose, medium dose and high dose indicated a reduction of 23.9%, 33.4% and 55.8% in mean tumor size, respectively. |