24512-63-8
24512-63-8 結(jié)構(gòu)式
基本信息
梔子甙
梔子苷
去羥基梔子甙
枝子苷,京尼平苷
Methyl (1R,2S,6S)-9-(hydroxymethyl)-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
Methyl (1R,2S,6S)-9-(hydroxymethyl)-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-,methyl ester, (1S,4aS,7aS)-
(1S)-1α-(β-D-Glucopyranosyloxy)-1,4aα,5,7aα-tetrahydro-7-hydroxymethylcyclopenta[c]pyran-4-carboxylic acid methyl ester
1α-(β-D-Glucopyranosyloxy)-1,4aα,5,7aα-tetrahydro-7-(hydroxymethyl)cyclopenta[c]pyran-4-carboxylic acid methyl ester
物理化學(xué)性質(zhì)
應(yīng)用領(lǐng)域
藥理藥效:梔子苷具有緩瀉、鎮(zhèn)痛、利膽、抗炎、治療軟組織損傷以及抑制胃液分泌和降低胰淀粉酶等作用。
常見問題列表
京尼平苷又稱梔子甙、京尼平甙，外觀為棕色至白色結(jié)晶性粉末，氣微，無苦味，是從茜草科植物梔子的干燥成熟果實(shí)中提取的一種環(huán)烯醚萜苷類化合物，具有顯著的促進(jìn)膽汁的分泌作用。并能降低血中膽紅素，可促進(jìn)血液中膽紅素迅速排泄。
梔子苷對溶血性鏈球菌和皮膚真菌有抑制作用。有解熱、鎮(zhèn)痛、鎮(zhèn)靜、降壓及止血作用。瀉火除煩，清熱利濕，涼血解毒，消腫止痛。主治熱病心煩，躁擾不寧，高熱煩躁，神昏譫語，黃疸尿赤，熱淋澀痛，血熱吐衄，目赤腫痛，火毒瘡瘍；外治扭挫傷痛。
Geniposide exhibits a variety of activities, such as on antithrombosis, anti-inflammation, anti-diabetes, anti-atherosclerosis, antidepression, healing Alzheimer’s disease (AD), anti-hypertension, toxicology, and untoward reaction are summarized. Geniposide markedly declines the production of IL-8, IL-1β and MCP-1 in OGD-induced brain microvascular endothelial cells, the expression of P2Y14 receptor is significantly down-regulated, the phosphorylation of RAF-1, MEK1/2, ERK1/2 are suppressed.
Geniposide (200 and 400 mg/kg) significantly decreases the blood glucose, insulin and TG levels in diabetic mice in a dose-dependent manner. This compound also decreases the expression of GP and G6Pase at mRNA and immunoreactive protein levels, as well as enzyme activity. Geniposide (20.0, 40.0, or 80 mg/kg) significantly reverses the excessive, alcohol-induced elevation in both serum ALT/AST and hepatic LPO levels. Geniposide upregulates the expression of heme oxygenase-1 (HO-1) to attenuate the cell apoptosis induced by 3-morpholinosydnonimine hydrochloride (SIN-1) in primary cultured hippocampal neurons. Geniposide inhibits photochemistry-induced thromboembolism model in vivo . Geniposide are very effective depressants on NF-κB by interrupting IκB degradation.