133-67-5
中文名稱
三氯噻嗪
英文名稱
Trichlormethiazide
CAS
133-67-5
EINECS 編號
205-118-8
分子式
C8H8Cl3N3O4S2
MDL 編號
MFCD00057315
分子量
380.66
MOL 文件
133-67-5.mol
更新日期
2024/10/28 10:43:07
133-67-5 結(jié)構(gòu)式
基本信息
中文別名
三氯噻嗪 英文別名
6-CHLORO-3-DICHLOROMETHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDETRICHLORMETHIAZIDE
TRICHLOROMETHIAZIDE
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(dichloromethyl)-3,4-dihydr
3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
3-dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1
3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-d
3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio
3-dichloromethylhydrochlorothiazide
6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonam
6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamid
6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-thiadiazine-7-sulfonamide1,1-dioxide
6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide
6-chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1
6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio
Achletin
Anistadin
所屬類別
原料藥：利尿藥物理化學(xué)性質(zhì)
熔點(diǎn)248-250℃
沸點(diǎn)631.3±65.0 °C(Predicted)
密度1.748
折射率1.6000 (estimate)
儲存條件Keep in dark place,Inert atmosphere,Room temperature
溶解度可溶于DMSO（少許）、甲醇（少許）
酸度系數(shù)(pKa)pKa 6.9(acetone/H2O) (Uncertain)
形態(tài)固體
顏色白色至灰白色
Merck9624
CAS 數(shù)據(jù)庫133-67-5(CAS DataBase Reference)
EPA化學(xué)物質(zhì)信息Trichlormethiazide (133-67-5)
安全數(shù)據(jù)
警示詞危險
危險性描述H317-H334
危險品標(biāo)志Xn
危險類別碼R42/43
安全說明S36
WGK Germany2
RTECS號DK8925000
海關(guān)編碼2935904000
毒害物質(zhì)數(shù)據(jù)133-67-5(Hazardous Substances Data)
毒性LD50 orally in rats: >20000 mg/kg (Goldenthal)
知名試劑公司產(chǎn)品信息
Sigma Aldrich
133-67-5(sigmaaldrich)TCI Shanghai
三氯噻嗪Trichloromethiazide,>99.0%(T)(133-67-5)
三氯噻嗪價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/08/19 | HY-B0235 | 三氯噻嗪 Trichlormethiazide | 133-67-5 | 500mg | 400元 |
| 2024/08/19 | HY-B0235 | 三氯噻嗪 Trichlormethiazide | 133-67-5 | 10mM * 1mLin DMSO | 500元 |
| 2024/08/19 | HY-B0235 | 三氯噻嗪 Trichlormethiazide | 133-67-5 | 1g | 500元 |
常見問題列表
生物活性
Trichlormethiazide 是一種利尿劑，具有與Hydrochlorothiazide相似的特性。體內(nèi)研究
Trichlormethiazide (10 mg/kg, i.v.; daily; for 5 days) significantly reduces mean arterial pressure (MAP) within 24 h in high salt intake (HS) rats receiving angiotensin II, but does not affect MAP in any other group.
| Animal Model: | Male Sprague-Dawley rats (350-450 g) |
| Dosage: | 10 mg/kg |
| Administration: | Intravenous injection, daily, for 15 days |
| Result: | Produced a significant fall in MAP in rats on combined angiotensin II and high salt intake. |