1320288-19-4
中文名稱
UNC 0631
英文名稱
UNC 0631
CAS
1320288-19-4
分子式
C37H61N7O2
分子量
635.93
MOL 文件
1320288-19-4.mol
更新日期
2024/11/15 18:20:32
1320288-19-4 結構式
基本信息
中文別名
G9A抑制劑(UNC 0631)N-[1-(環(huán)己基甲基)-4-哌啶基]-2-[六氫-4-異丙基-1H-1,4-二氮雜卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺
英文別名
CS-793UNC 0631
UNC 0631, >=98%
UNC0631/UNC-0631
UNC 0631 USP/EP/BP
UNC0631
UNC 0631
UNC-0631
N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-(4-isopropyl-1,4-diazepa n-1-yl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
N-(1-(cyclohexylmethyl)piperidin-4- yl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-(3-(piperidin-1- yl)propoxy)quinazolin-4-amine
N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine
4-Quinazolinamine, N-[1-(cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-
所屬類別
生物化工：Histone Methyltransferase 抑制劑物理化學性質(zhì)
沸點763.4±70.0 °C(Predicted)
密度1.114±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度insoluble in H2O; ≥12.66 mg/mL in EtOH with ultrasonic; ≥18.35 mg/mL in DMSO with gentle warming
酸度系數(shù)(pKa)9.34±0.70(Predicted)
形態(tài)固體
顏色Light yellow to yellow
常見問題列表
生物活性
UNC 0631 是一種有效的組蛋白甲基轉移酶 G9a 抑制劑，IC50 值為 4 nM。UNC 0631 有效降低 MDA-MB-231 細胞中 H3K9me2 的水平，IC50 為 25 nM。靶點
|
G9a 4 nM (IC 50 ) |
體外研究
UNC 0631 (Compound 7) has high cellular potency and excellent separation of functional potency versus cell toxicity in a variety of cell lines. UNC 0631 is highly potent in reducing H3K9me2 levels and has low cell toxicity. UNC 0631 reduces H3K9me2 levels with ICW IC 50 values of 25 nM, 18 nM, 26 nM, 24 nM, 51 nM, 72 nM and 46 nM in MDA-MB-231, MCF7, PC3, 22RV1, HCT116 wt, HCT 116 p53 -/- and IMR90 cell lines, respectively.