127243-85-0

基本信息
N-[2-[P-溴苯丙烯鹽基氨基]乙基]-5-異喹啉磺酰胺
H-89 DIHYDROCHLORIDE
H-89 HYDROCHLORIDE
N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE
N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL
N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, DIHYDROCHLORIDE
N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE
N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE
物理化學性質(zhì)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2025/02/08 | HY-15979A | N-[2-[P-溴苯丙烯鹽基氨基]乙基]-5-異喹啉磺酰胺 H-89 dihydrochloride | 127243-85-0 | 5 mg | 385元 |
2025/02/08 | HY-15979A | N-[2-[P-溴苯丙烯鹽基氨基]乙基]-5-異喹啉磺酰胺 H-89 dihydrochloride | 127243-85-0 | 10mg | 606元 |
2025/02/08 | HY-15979A | N-[2-[P-溴苯丙烯鹽基氨基]乙基]-5-異喹啉磺酰胺 H-89 dihydrochloride | 127243-85-0 | 10mM * 1mLin DMSO | 678元 |
常見問題列表
IC50: 48 nM (protein kinase A)
H-89 inhibits protein kinase A, in competitive fashion against ATP. H-89 causes a dose-dependent inhibition of the forskolin-induced protein phosphorylation, with no decrease in intracellular cyclic AMP levels in PC12D cells. H-89 significantly inhibits the forskolin-induced neurite outgrowth from PC12D cells. H-89 (30 μM) inhibits significantly cAMP-dependent histone IIb phosphorylation activity in PC12D cell lysates. H-89 (1-2 μM) significantly slows the repriming rate in rat skinned fibres, most likely due to it deleteriously affecting the T-system potential. H-89 (10-100 μM) inhibits net Ca 2+ uptake by the SR and affectes the Ca 32 -sensitivity of the contractile apparatus in rat skinned fibres.
H-89 (0.2 mg/100g, i.p.) significantly increases seizure latency and threshold in PTZ-treated animals. H-89 (0.05, 0.2 mg/100 g, i.p.) prevents the epileptogenic activity of bucladesine (300 nM) with significant increase of seizure latency and seizure threshold.