1222781-70-5
中文名稱
(4-甲氧基芐基)(1-萘基甲基)胺鹽酸鹽
英文名稱
ML 133 Hydrochloride
CAS
1222781-70-5
分子式
C19H20ClNO
分子量
313.821
MOL 文件
1222781-70-5.mol
1222781-70-5 結(jié)構(gòu)式
基本信息
中文別名
ML133鹽酸鹽(4-甲氧基芐基)(1-萘基甲基)胺鹽酸鹽
N-[(4-甲氧基苯基)甲基]-1-萘甲胺鹽酸鹽
N-(4-甲氧基芐基)-1-(萘-1-基)甲胺鹽酸鹽
ML133 HCL (4-甲氧基芐基)(1-萘基甲基)胺鹽酸鹽
英文別名
ML133 HClML 133 Hydrochloride
CID 781301 hydrochloride
VU0404943-1 hydrchloride
SID 85281105 hydrochloride
ML 133 Hydrochloride USP/EP/BP
(4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride
N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride
N-[(4-METHOXYPHENYL)METHYL]-1-NAPHTHALENEMETHANAMINE HYDROCHLORIDE
(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride
所屬類別
生物化工：Potassium Channel 抑制劑安全數(shù)據(jù)
常見問題列表
生物活性
ML133 HCl是一種選擇性鉀離子通道抑制劑，作用于Kir2.1， IC50為1.8 μM (pH 7.4)和290 nM (pH 8.5)，對Kir1.1沒有作用效果，對Kir4.1和Kir7.1具有微弱的作用活性。體外研究
The ratio of total concentration of extracellular ML133 versus intracellular ML133 is 1:0.13 at pH 6.5, 1:9.09 at pH 8.5. ML133 is clean against 3A4 and 2C9 (IC50 >30 μM), displays moderate inhibition of 1A2 (IC50 = 3.3 μM) but proves to be a potent inhibitor of 2D6 (IC50 = 0.13 μM) in CYP450 assay. ML133 is highly protein bound (>99%) in both human and rat and also displays high intrinsic clearance in both species. ML133 (10 μM) is not displaced by K+ influx from the wild-type Kir2.1 in HEK 293 cells. M1 and/or M2 transmembrane domains contain the critical molecular determinant for ML133 inhibition of Kir2.1, especially D172 and I176.靶點
IC50: 1.8 μM (K ir 2 at pH 7.4), 290 nM (K ir 2 at pH 8.5).
(4-甲氧基芐基)(1-萘基甲基)胺鹽酸鹽價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/08/19 | HY-100230A | (4-甲氧基芐基)(1-萘基甲基)胺鹽酸鹽 ML133 hydrochloride | 1222781-70-5 | 5mg | 500元 |
| 2024/08/19 | HY-100230A | (4-甲氧基芐基)(1-萘基甲基)胺鹽酸鹽 ML133 hydrochloride | 1222781-70-5 | 10mM * 1mLin DMSO | 550元 |
| 2024/08/19 | HY-100230A | (4-甲氧基芐基)(1-萘基甲基)胺鹽酸鹽 ML133 hydrochloride | 1222781-70-5 | 10mg | 700元 |