120-21-8
中文名稱
N,N-二乙基-4-氨基苯甲醛
英文名稱
4-Diethylaminobenzaldehyde
CAS
120-21-8
EINECS 編號(hào)
204-377-4
分子式
C11H15NO
MDL 編號(hào)
MFCD00003382
分子量
177.24
MOL 文件
120-21-8.mol
更新日期
2024/11/04 16:39:22
120-21-8 結(jié)構(gòu)式
基本信息
中文別名
N,N-二乙基-4-氨基苯甲醛對(duì)二乙氨基苯甲醛
4-二乙氨基苯甲醛
N,N-二乙氨基苯甲醛
對(duì)(N,N-二乙基)苯甲醛
對(duì)-二乙氨基苯甲醛
4-(N,N-二乙基)氨基苯甲醛
4-(N,N-二乙胺基)苯甲醛
二乙基氨苯甲醯
4-二乙胺基苯甲醛
4-二乙基氨基苯甲醛
英文別名
4-DIETHYLAMINOBENZALDEHYDE4-(N,N-DIETHYLAMINO)BENZALDEHYDE
AKOS BBS-00003202
DEAB
LABOTEST-BB LT00924385
N,N-DIETHYL-4-AMINO BENZALDEHYDE
P-DIETHYLAMINOBENZALDEHYDE
P-FORMYL-N,N-DIETHYLANILINE
P-(N,N'-DIETHYLAMINO) BENZALDEHYDE
P-N,N-DIETHYLAMINOBENZALDEHYDE
(diethylamino)benzaldehyde
4-(diethylamino)-benzaldehyd
Benzaldehyde, p-(diethylamino)-
benzaldehyde,-(diethylamino)-
Benzaldehyde,4-(diethylamino)-
N,N-Diethylaminobenzaldehyde
4-Diethylaminobenzoaldehyde
4-Diethylaminobenzaldehyde99%
4-Diethylaminobenzaldehyde, 95+%
p-Diethylaminobenzaldehyd
物理化學(xué)性質(zhì)
外觀性狀黃色針狀結(jié)晶體。熔點(diǎn)39-41℃，沸點(diǎn)174℃（2.27kPa）。溶于乙醇、乙醚，不溶于水。
熔點(diǎn)37-41 °C(lit.)
沸點(diǎn)174 °C7 mm Hg(lit.)
密度1.03 g/cm3
折射率1.5302 (estimate)
閃點(diǎn)>230 °F
儲(chǔ)存條件Store below +30°C.
溶解度2.5g/l
酸度系數(shù)(pKa)3.36±0.32(Predicted)
形態(tài)粗晶體、大塊或結(jié)晶固體
顏色棕色到綠色再到黑色
水溶解性insoluble
敏感性空氣敏感
檢測方法HPLC
BRN511102
CAS 數(shù)據(jù)庫120-21-8(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息Benzaldehyde, 4-(diethylamino)-(120-21-8)
EPA化學(xué)物質(zhì)信息Benzaldehyde, 4-(diethylamino)- (120-21-8)
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H312-H315-H319-H335
危險(xiǎn)品標(biāo)志Xi,N,Xn
危險(xiǎn)類別碼R36/37/38-R50/53-R21/22
WGK Germany2
RTECS號(hào)CU5612850
TSCAYes
海關(guān)編碼29223990
制備方法
方法一
將二乙基苯胺、烏洛托品和90%乙醇混勻，加熱回流，加入冰乙酸和90%甲酸，保溫過夜。將反應(yīng)液傾入預(yù)冷的鹽酸中，過濾，粗品經(jīng)酸堿重結(jié)晶、乙醇重結(jié)晶得對(duì)二乙氨基苯甲醛。知名試劑公司產(chǎn)品信息
Acros Organics
4-二乙胺基苯甲醛4-(Diethylamino)benzaldehyde, 99%(120-21-8)
Sigma Aldrich
120-21-8(sigmaaldrich)N,N-二乙基-4-氨基苯甲醛價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | A11825 | 4-二乙基氨基苯甲醛, 97% 4-Diethylaminobenzaldehyde, 97% | 120-21-8 | 100g | 490元 |
| 2024/08/19 | A11825 | 4-二乙基氨基苯甲醛, 97% 4-Diethylaminobenzaldehyde, 97% | 120-21-8 | 500g | 1368元 |
| 2024/08/19 | 11400 | N,N-二乙基-4-氨基苯甲醛 4-(Diethylamino)benzaldehyde, 99%, Thermo Scientific Chemicals | 120-21-8 | 100g | 640元 |
常見問題列表
生物活性
4-Diethylaminobenzaldehyde 是一種可逆的醛脫氫酶 (ALDHs) 抑制劑，對(duì) ALDH1 的 Ki 為 4 nM。4-Diethylaminobenzaldehyde 具有較強(qiáng)的抗雄激素作用 (IC50= 1.71 μM)。體外研究
4-Diethylaminobenzaldehyde (DEAB) is reversible competitive inhibitor of ALDH1 (competitive with the aldehyde substrate) with a K
i
value of 4 nM, and irreversibly inactivates ALDH7A1 via formation of a stable, covalent acyl-enzyme species.
The Temozolomide (TMZ)-resistant cell line LN18 is treated with a combination of TMZ and 4-Diethylaminobenzaldehyde for 10 days. As indicated by colony formation assay, the clonogenic capacity of LN18 cells exposed to TMZ in combination with 4-Diethylaminobenzaldehyde (DEAB) is significantly attenuated.