119478-56-7
119478-56-7 結(jié)構(gòu)式
基本信息
美羅培南USP版
三水合美羅培南
3-[5-(二甲基氨基甲酰基)哌啶-3-基]硫]-6-(1-羥乙基)-4-甲基-7-氧代-1-氮雜二環(huán)[3.2.0]庚-2-烯-2-甲酸
美洛培南
MEROPENEM TRIHYDRATE
MEROPENEM TRIHYDROCHLORIDE
(4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid trihydrate
1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[5-[(dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-, trihydrate, [4R-[3(3S*,5S*),4a,5b,6b(R*)]]- (9CI)
3-[[5-[(Dimethylamino)carbonyl]-3-pyrrolidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-carboxylic acid trihydrate
(4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)pyrrolidin-3-yl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Meropenem
MEROPENEMTRIHYDRATE(3-[[5-[(DIMETHYLAMINO)CARBONYL]-3-PYRROLIDINYL]THIO]-6-(1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO[3,2,0]HEPT-2-ENE-2-CARBOXYLICACIDTRIHYDRATE)
MEROPENEM WITH SODIUM CARBONATE
物理化學(xué)性質(zhì)
常見問題列表
美洛培南三水合物具有極廣的抗菌譜、極強(qiáng)的抗菌活性，及對多種B-內(nèi)酰胺酶和DHP-1穩(wěn)定。
以保護(hù)美羅培南為原料，以單一溶劑水為反應(yīng)溶媒，在堿和催化劑存在的條件下，采用非氫還原劑進(jìn)行脫保護(hù)反應(yīng)，制得目標(biāo)產(chǎn)物美羅培南三水化合物。
Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia.
Meropenem (60 mg/kg; intraperitoneal injection; once; SD rats) treatment significantly reduces the incidence of pancreatic infection.
| Animal Model: | Male Sprague-Dawley rats (250-350 g) induced acute necrotizing pancreatitis |
| Dosage: | 60 mg/kg |
| Administration: | Intraperitoneal injection; once |
| Result: | Significantly reduced the incidence of pancreatic infection. |