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110429-35-1

中文名稱 鹽酸帕羅西汀
英文名稱 PAROXETINE-D4 HCL
CAS 110429-35-1
分子式 C19H17ClD4FNO3
分子量 369.85
MOL 文件 110429-35-1.mol
更新日期 2024/10/29 11:31:14
110429-35-1 結(jié)構(gòu)式 110429-35-1 結(jié)構(gòu)式

基本信息

中文別名
半水帕羅西汀
D4-鹽酸帕羅西汀
鹽酸帕羅西汀半水合物
鹽酸帕羅西汀半水合物, 選擇性5-羥色胺重吸收抑制劑 (SSRI)
(辦證)鹽酸帕羅西汀PAROXETINE HYDROCHLORIDE HEMIHYDRAT
(-)-(3S,4R)-PAROXETINE HYDROCHLORIDE HEMIHYDRATE
(-)-反式-4R-(4-氟苯基)-3S-{[3',4'-(亞甲二氧基)苯氧基]甲基}-哌啶鹽酸鹽半水合物
英文別名
PAROXETINE-D4 HCL
BRL29060A hemihydrate
PAROXETINE HCL HEMIHYDRATE
Paroxetine-D4 hydrochloride
PAROXETINE-D4 HCL USP/EP/BP
PAROXETINE HYDROCHLORIDE 1/2H2O
paroxetine hydrochloride hydrate
Paroxetine Hydrochloride (350 mg)
PAROXETINE HEMIHYDRATE, EP/BP/USP
BRL29060 hydrochloride hemihydrate
所屬類別
原料藥:抗抑郁、躁狂藥

物理化學(xué)性質(zhì)

熔點(diǎn)121-131 C
儲(chǔ)存條件Inert atmosphere,2-8°C
溶解度Slightly soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent) and in methylene chloride.
形態(tài)粉末
顏色白色
最大波長(zhǎng)(λmax)292nm(H2O)(lit.)
Merck14,7043
CAS 數(shù)據(jù)庫(kù)110429-35-1

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
警示詞警告
危險(xiǎn)性描述H302-H317-H319-H411
危險(xiǎn)品標(biāo)志F,C,Xn
危險(xiǎn)類別碼11-34-36/37/38-22
安全說(shuō)明16-26-36/37/39-45-36
危險(xiǎn)品運(yùn)輸編號(hào)UN 3077 9 / PGIII
WGK Germany3
RTECS號(hào)TM4569320
危險(xiǎn)等級(jí)IRRITANT
海關(guān)編碼29349990

上下游產(chǎn)品信息

上游原料
下游產(chǎn)品
帕羅西汀
鹽酸帕羅西汀價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/1946263鹽酸帕羅西汀半水合物
Paroxetine hydrochloride hemihydrate, 98%
110429-35-11g602元
2024/08/1946263鹽酸帕羅西汀半水合物
Paroxetine hydrochloride hemihydrate, 98%
110429-35-15g2055元
2024/08/19P1977鹽酸帕羅西汀 半水合物
Paroxetine Hydrochloride Hemihydrate
110429-35-11g70元

常見問(wèn)題列表

生物活性
Paroxetine hydrochloride hemihydrate 是一種抗抑郁藥,為高效的五羥色胺再攝取抑制劑,能抑制 GRK2 活性,IC50 值為 14?μM。
靶點(diǎn)

IC50: 14?μM (GRK2)

體外研究

Paroxetine (1?μM and 10?μM) distinctly restrains T cell migration induced by CX3CL1 through inhibiting GRK2. Paroxetine inhibits GRK2 induced activation of ERK. Paroxetine (10 μM) reduces pro-inflammatory cytokines in LPS-stimulated BV2 cells. Paroxetine (0-5 μM) leads to a dose-dependent inhibition on LPS-induced production of TNF-α and IL-1β in BV2 cells. Paroxetine also inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BV2 cells. Paroxetine (5 μM) blocks LPS-induced JNK activation and attenuates baseline ERK1/2 activity in BV2 cells. Paroxetine relieves microglia-mediated neurotoxicity, and suppresses LPS-stimulated pro-inflammatory cytokines and NO in primary microglial cells.

體內(nèi)研究

Paroxetine treatment obviously attenuates the symptoms of CIA rats. Paroxetine treatment clearly prevents the histological damage of joints and alleviates T cells infiltration into synovial tissue. Paroxetine reveals a strong effect on inhibiting CX3CL1 production in synovial tissues. Paroxetine (20 mg/kg/day) reduces the myocyte cross-sectional area in rat and ROS formation in the remote myocardium. Paroxetine reduces the susceptibility to ventricular tachycardia. Paroxetine treatment following MI decreases LV remodeling and susceptibility to arrhythmias, probably by reducing ROS formation. In CCI paroxetine-treated group, paroxetine (10 mg/kg, i.p.) produces hyperalgesia at days 7 and 10 (P<0.01), but a decrease in pain behavior is seen at day 14. Moreover, paroxetine (10 mg/kg) significantly attenuates tactile hypersensitivity when compared to CCI vehicle-treated group.

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