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10563-70-9

中文名稱 鹽酸美利曲辛
英文名稱 Melitracen hydrochloride
CAS 10563-70-9
EINECS 編號 234-150-5
分子式 C21H26ClN
分子量 327.891
MOL 文件 10563-70-9.mol
更新日期 2024/12/20 09:28:19
10563-70-9 結(jié)構(gòu)式 10563-70-9 結(jié)構(gòu)式

基本信息

中文別名
鹽酸美利蒽
鹽酸美利曲辛
3-[10,10-二甲基-9(10H)-蒽亞基]-N,N-二甲基丙胺鹽酸鹽
英文別名
3-[10,10-dimethyl-9(10H)-anthrylidene]-N,N-dimethylpropylamine hydrochloride
MELITRACEN HYDROCHLORLD
1-Propanamine, 3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-, hydrochloride
MELITRACEN HYDROCHLORID
Melitracen hydrochloride
3-(10,10-Dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine Hydrochloride
9-(3-Dimethylaminopropylidene)-10,10-dimethyl-9,10-dihydroanthracene Hydrochloride
Adaptol
Melixeran
Thymeol
Trausabun
U-24973A
3-(10,10-Dimethyl-d6)-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine Hydrochloride
9-(3-Dimethylaminopropylidene)-10,10-(dimethyl-d6)-9,10-dihydroanthracene Hydrochloride
Adaptol-d6
Melitracen-d6 Hydrochloride
Melitracene-d6
Melixeran-d6
Thymeol-d6
Trausabun-d6
所屬類別
原料藥:抗抑郁、躁狂藥

物理化學(xué)性質(zhì)

熔點245-248°C
儲存條件Sealed in dry,Room Temperature
溶解度溶于二甲基亞砜
CAS 數(shù)據(jù)庫10563-70-9(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
毒性LD50 i.v. in mice: 52 mg/kg (Petersen)

常見問題列表

生物活性
Melitracen hydrochloride (Thymeol)是一種潛在的dopamine D1/2 receptor拮抗劑,具有抗抑郁作用。
靶點

5-HT receptor

體內(nèi)研究

Single oral administration of either Imipramine or Melitracen produces a marked and long lasting mydriasis in mice. The mydriatic effect of Melitracen is more marked and longer lasting. Melitracen is more effective with respect to behavioral excitement. Single oral administration of Melitracen produces lowering of the catechol amine levels in the brain stem, the cerebral cortex, the spleen, and the adrenals.
No significant changes in catecholamine levels of the brain stem, the cerebral cortex, and the spleen were observed in rats receiving daily doses of Melitracen for 13 and 15 weeks. The adrenalin level in the adrenals, however, is slightly decreased.

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