| Identification | More | [Name]
Methyl methanesulfonate | [CAS]
66-27-3 | [Synonyms]
METHANESULFONIC ACID METHYL ESTER
METHYL METHANESULFONATE
METHYL METHANESULPHONATE
MMS
as-Dimethyl sulphite
as-dimethylsulfite
as-dimethylsulphite
CB 1540
FDA 0092
Methanesulphonic acid methyl ester
methanesulphonicacidmethylester
Methyl ester of methanesulfonic acid
Methyl ester of methanesulphonic acid
Methyl mesylate
Methyl methansulfonate
Methyl methansulphonate
Methylester kyseliny methansulfonove
methylesterkyselinymethansulfonove
methylesterofmethanesulfonicacid
methylesterofmethanesulphonicacid | [EINECS(EC#)]
200-625-0 | [Molecular Formula]
C2H6O3S | [MDL Number]
MFCD00007557 | [Molecular Weight]
110.13 | [MOL File]
66-27-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear, colorless to amber liquid. | [Melting point ]
20°C | [Boiling point ]
202-203 °C(lit.) | [density ]
1.3 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.8 hPa (59 °C) | [refractive index ]
n20/D 1.414(lit.)
| [Fp ]
220 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
200g/l | [form ]
Liquid | [color ]
Colorless to pale yellow | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. | [Water Solubility ]
200 g/L (20 ºC) | [Merck ]
6097 | [BRN ]
1098586 | [InChIKey]
MBABOKRGFJTBAE-UHFFFAOYSA-N | [CAS DataBase Reference]
66-27-3(CAS DataBase Reference) | [IARC]
2A (Vol. 7, Sup 7, 71) 1999 | [NIST Chemistry Reference]
Methanesulfonic acid, methyl ester(66-27-3) | [EPA Substance Registry System]
Methyl methanesulfonate (66-27-3) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R45:May cause cancer.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R68:Possible risk of irreversible effects. | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
PB2625000
| [F ]
21 | [TSCA ]
Yes | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29341000 | [Safety Profile]
Confirmed carcinogen
with carcinogenic and neoplastigenic data.
Poison by ingestion, intraperitoneal,
intravenous, and subcutaneous routes.
Human mutation data reported.
Experimental teratogenic and reproductive
effects. When heated to decomposition it
emits toxic fumes of SOx. | [Hazardous Substances Data]
66-27-3(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 225 mg/kg |
| Hazard Information | Back Directory | [General Description]
Colorless to amber liquid. | [Reactivity Profile]
METHYL METHANESULFONATE(66-27-3) is incompatible with strong oxidizing agents, strong acids and strong bases. | [Air & Water Reactions]
Water soluble. | [Potential Exposure]
Research chemical and cancer drug.
No longer produced commercially in the United States. | [Fire Hazard]
This chemical is combustible. | [First aid]
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult. Remove and
isolate contaminated clothing and shoes. In case of contact
with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact,
avoid spreading material on unaffected skin. Keep victim
warm and quiet. Effects of exposure (inhalation, ingestion,
or skin contact) to substance may be delayed. Ensure that
medical personnel are aware of the material(s) involved
and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing
overexposure, as pulmonary edema may be delayed. As
first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy. | [Shipping]
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
| [Incompatibilities]
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Esters are generally
incompatible with nitrates. Moisture may cause hydrolysis
or other forms of decomposition | [Chemical Properties]
Clear, colorless to amber liquid. | [Chemical Properties]
colourless liquid | [Waste Disposal]
It is inappropriate and possibly dangerous to the environment to dispose of lab chemicals or expired or waste drugs and pharmaceuticals by
flushing them down the toilet or discarding them to the
trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee
grounds, double-bagged in plastic, discard in trash.
Larger quantities shall carefully take into consideration
applicable DEA, EPA, and FDA regulations. If possible
return the pharmaceutical to the manufacturer for proper
disposal being careful to properly label and securely
package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported
by a state licensed medical waste contractor to dispose by
burial in a licensed hazardous or toxic waste landfill or
incinerator. | [Uses]
Experimentally as mutagen, teratogen, brain carcinogen. | [Uses]
Methyl methanesulfonate is a DNA adduct that adds methyl groups to Dan at 7-guanine, 3-guanine and 3-adenine. | [Definition]
ChEBI: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol. | [Carcinogenicity]
Methyl methanesulfonate is reascarcinogen based on sufficient evi
onably anticipated to be a human dence of carcinogenicity from studies in experimental animals. | [Purification Methods]
Purify the ester by careful fractionation and collecting the middle fraction. Suspected CARCINOGEN. Note that MeSO3H has b 167-167.5o/10mm and methanesulfonic anhydride has b 138o/10mm)—both are possible impurities. [Beilstein 4 IV 11.] |
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