| Identification | More | [Name]
1,3-Propanesultone | [CAS]
1120-71-4 | [Synonyms]
1,2-OXATHIOLANE, 2,2-DIOXIDE
1,3-PROPANESULTONE
3-HYDROXY-1-PROPANESULFONIC ACID GAMMA-SULTONE
3-HYDROXY-1-PROPANESULFONIC ACID SULTONE
3-HYDROXY-1-PROPANE SULFONIC SULTONE
3-HYDROXYPROPANESULFONIC ACID GAMMA-SULTONE
3-HYDROXYPROPANESULFONIC ACID SULTONE
PROPANE SULTONE
1,2-oxathrolane2,2-dioxide
1-Propanesulfonic acid, 3-hydroxy-, gamma-sultone
1-propanesulfonicacid-3-hydroxy-gamma-sultone
1-propanesulfonicacid-3-hydroxy-gamma-sultone[qr]
3-hydroxy-1-propanesulfonicacidw-sultone
3-Hydroxy-1-propanesulphonic acid sulfone
3-Hydroxy-1-propanesulphonic acid sultone
3-hydroxy-1-propanesulphonicacidsulfone
3-hydroxy-1-propanesulphonicacidsultone
3-hydroxy-1-propanesulphonicacidsultone[qr]
3-hydroxythietane-1,1-dioxide[qr]
gamma-Propane sultone | [EINECS(EC#)]
214-317-9 | [Molecular Formula]
C3H6O3S | [MDL Number]
MFCD00005355 | [Molecular Weight]
122.14 | [MOL File]
1120-71-4.mol |
| Chemical Properties | Back Directory | [Appearance]
1,3-Propane sultone is a white crystalline solid
or a colorless liquid above 30 ? C. It releases a foul odor as
it melts. | [Melting point ]
30-33 °C (lit.) | [Boiling point ]
180 °C/30 mmHg (lit.) | [density ]
1.392 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.001-0.48Pa at 20-25℃ | [refractive index ]
1.4332 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
powder | [Usage]
1,3-Propane sultone(1120-71-4) belongs to functional fine chemical new-type material. 1,3-Propanesultone(1120-71-4) can react with various compounds under quite mild conditions, accurately provide sulfonic groups, and endow these compounds with new properties (such as hydrophilicity, static electricity resistance). It is a good general purposed sulfonating agent, a kind of important medicine intermediate, and also the key material to synthesize important electroplating additive intermediate PPS, UPS, DPS, MPS, ZPS, POPS, SP, etc. 1,3-Propanesultone(1120-71-4) can also be used in brightening agent, dyes, di-ionic surface active agent, sulfonating agent and lithium cells, etc. | [color ]
White or Colorless to Light yellow | [Stability:]
Stable, but moisture sensitive. Incompatible with strong oxidizing agents, strong acids, strong bases. | [Water Solubility ]
Slightly soluble | [FreezingPoint ]
30.0 to 33.0 ℃ | [Sensitive ]
Moisture Sensitive | [BRN ]
109782 | [Uses]
1,3-Propanesultone(1120-71-4) is an important chemical intermediates that used as the startingmaterial for many electroplating chemical intermediates,sensitizing dye anionic Gemini surfactants. In addition, 1,3-Propanesultone is used intosecondary lithium ion solution to improve recycling life. | [InChIKey]
FSSPGSAQUIYDCN-UHFFFAOYSA-N | [LogP]
-2.86--0.28 at 20℃ | [CAS DataBase Reference]
1120-71-4(CAS DataBase Reference) | [IARC]
2A (Vol. 4, Sup 7, 71, 110) 2017 | [NIST Chemistry Reference]
1,2-Oxathiolane, 2,2-dioxide(1120-71-4) | [EPA Substance Registry System]
1120-71-4(EPA Substance) | [Storage condition]
Stored in cool and dry place |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R45:May cause cancer.
R21/22:Harmful in contact with skin and if swallowed . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
RP5425000
| [F ]
21 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29349900 | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic, and
teratogenic data. Poison by subcutaneous
route. Moderately toxic by skin contact and
intraperitoneal routes. Human mutation data
reported. Implicated as a human brain
carcinogen. A slun irritant. When heated to
decomposition it emits toxic fumes of SOx. | [Hazardous Substances Data]
1120-71-4(Hazardous Substances Data) | [Toxicity]
mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),SKIN AND APPENDAGES (SKIN): HAIR: OTHERSENSE ORGANS AND SPECIAL SENSES: OTHER: EYEBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),National Technical Information Service. Vol. OTS0555330, |
| Hazard Information | Back Directory | [General Description]
White crystalline solid or a colorless liquid. Melting point 86°F. Releases a foul odor when melting. | [Reactivity Profile]
PROPANE SULTONE(1120-71-4) reacts slowly with water to give 3-hydroxopropanesulfonic acid. This reaction may be accelerated by acid. May react with strong reducing agents to give toxic and flammable hydrogen sulfide. | [Air & Water Reactions]
Soluble in water [Hawley]. | [Hazard]
Possible carcinogen.
| [Potential Exposure]
A potential danger to those involved
in use of this chemical intermediate to introduce the sulfo-
propyl group (-CH 2 CH 2 CH 2 SO 3-) into molecules of
other products. | [First aid]
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respira-
tion with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult. Remove and
isolate contaminated clothing and shoes. In case of contact
with substance, immediately flush skin or eyes with run-
ning water for at least 20 minutes. For minor skin contact,
avoid spreading material on unaffected skin. Keep victim
warm and quiet. Effects of exposure (inhalation, ingestion
or skin contact) to substance may be delayed. Ensure that
medical personnel are aware of the material(s) involved
and take precautions to protect themselves. Medical obser-
vation is recommended for 24?48 hours after breathing
overexposure, as pulmonary edema may be delayed.
As first aid for pulmonary edema, a doctor or authorized
paramedic may consider administering a drug or other
inhalation therapy. | [Shipping]
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. UN2810 Toxic liquids, organic, n.o.s.,
Hazard Class: 6.1; Labels: 6.1-Poisonous materials,
Technical Name Required. | [Incompatibilities]
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explo-
sions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. | [Description]
Propane sultone also known as 1,3-propane sultone was first
produced in the United States in 1963. Propane sultone exists
at room temperature as a colorless liquid with a foul odor or as
a white crystalline solid. | [Chemical Properties]
1,3-Propane sultone is a white crystalline solid
or a colorless liquid above 30 ? C. It releases a foul odor as
it melts. | [Chemical Properties]
White To Off-White low melting Solid | [Waste Disposal]
C 9 H 9 Cl 2 NO; Cl 2 C 6 H 3 NHCOC 2 H5 | [Application]
1,3-Propanesultone(1120-71-4) is a cyclic sulfonic ester mainly used to introduce a propane sulfonic functionality into the organic structure. It has been used in preparation of poly[2-ethynyl-N-(propylsulfonate)pyridinium betaine],novel poly(4-vinylpyridine) supported acidic ionic liquid catalyst,novel poly(4-vinylpyridine) supported acidic ionic liquid catalyst.
1,3-Propanesultone can be used to synthesize:
A sulfonic acid functionalized acidic ionic liquid modified silica catalyst that can be used in hydrolysis of cellulose.
Zwitterionic-type molten salts with unique ion conductive properties.
Zwitterionic organofunctional silicones by the quaternization of organic amine functional silicones.
| [Definition]
1,3-Propane sultone(1120-71-4) is used as a chemical intermediate. No information is available on the acute (short- term), chronic (long-term), reproductive, developmental, and carcinogenic effects of 1,3-propane sultone in humans. In rodents exposed to 1,3-propane sultone via gavage (experimentally placing the chemical in the stomach) and intravenous injection, tumors of the brain and other central nervous system (CNS) tissues have been observed. Leukemia, and tumors of the ear duct, small intestine, kidneys, lung, mammary gland, uterus, and skin have been reported in rodents exposed via gavage, injection, or dermal contact. The International Agency for Research on Cancer (IARC) has classified 1,3-propane sultone as a Group 2B, possible human carcinogen.
| [Preparation]
1,3-propane sultone is produced commercially by dehydrating gamma-hydroxy-propanesulfonic acid, which is prepared from sodium hydroxypropanesulfonate. this sodium salt is prepared by addition of sodium bisulfite to allyl alcohol.? | [Health Hazard]
Propane sultone is a carcinogen
in experimental animals and a suspected human
carcinogen. No human data are available.
It is a carcinogen in rats when given orally,
intravenously, or by prenatal exposure and a
local carcinogen in mice and rats when given
subcutaneously. | [Flammability and Explosibility]
Nonflammable | [Carcinogenicity]
1,3-Propane sultone is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. | [Environmental Fate]
Routes and Pathways and Relevant Physicochemical
Properties
Appearance: white crystalline solid or colorless liquid.
Solubilities: readily soluble in ketones, esters, and aromatic
hydrocarbons; insoluble in aliphatic hydrocarbons; and
soluble in water (100 g l-1).
Partition Behavior in Water, Sediment, and Soil
If 1,3-propane sultone is released to soil, it will be expected to
rapidly hydrolyze if the soil is moist, based upon the rapid
hydrolysis observed in aqueous solution. Since it rapidly
hydrolyzes, adsorption to and volatilization from moist soil are
not expected to be significant processes, although no data
specifically regarding the fate of 1,3-propane sultone in soil
were located. If released into water, it will be expected to rapidly hydrolyze. The produce of hydrolysis is 3-hydroxy-
1-propansulfonic acid. Since it rapidly hydrolyzes, bioconcentration,
volatilization, and adsorption to sediment and
suspended solids are not expected to be significant processes.
If released to the atmosphere, it will be susceptible to photooxidation
via vapor-phase reaction with photochemically
produced hydroxyl radicals with a half-life of 8 days estimated
for this process. | [Toxicity evaluation]
The reaction of propane sultone with guanosine and DNA at
pH 6–7.5 gave an N7-alkylguanosine as the main product
(>90%). Similar evidence suggested that two of the minor
adducts were N1- and N6-alkyl derivatives, accounting for
approximately 1.6 and 0.5% of the total adducts, respectively.
N7- and N1-alkylguanine were also detected in the DNA reacted
with propane sultone. | [Toxics Screening Level]
The initial threshold screening level (ITSL) for 1,3-propane sultone (CAS # 1120-71-4) is
2 μg/m3 annual averaging time. |
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