| Identification | More | [Name]
Ethyl methanesulfonate | [CAS]
62-50-0 | [Synonyms]
ETHYL MESYLATE
ETHYL METHANESULFONATE
ETHYL METHANESULPHONATE
METHANESULFONIC ACID ETHYL ESTER
CB 1528
EMS
ENT 26396
ent26396
Ethyl ester of methanesulfonic acid
Ethyl ester of methanesulphonic acid
Ethyl ester of methylsulfonic acid
Ethyl ester of methylsulphonic acid
Ethyl methansulfonate
Ethyl methansulphonate
Ethylester kyseliny methansulfonove
ethylesterkyselinymethansulfonove
ethylesterofmethanesulfonicacid
ethylesterofmethanesulphonicacid
ethylesterofmethylsulfonicacid
ethylesterofmethylsulphonicacid | [EINECS(EC#)]
200-536-7 | [Molecular Formula]
C3H8O3S | [MDL Number]
MFCD00007559 | [Molecular Weight]
124.16 | [MOL File]
62-50-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Ethyl methane sulfonate is a clear liquid. | [Melting point ]
<25 °C | [Boiling point ]
85-86 °C/10 mmHg (lit.) | [density ]
1.206 g/mL at 20 °C
| [vapor pressure ]
0.27 hPa (25 °C) | [refractive index ]
n20/D 1.418(lit.)
| [Fp ]
100 °C
| [storage temp. ]
2-8°C | [solubility ]
50-100g/l | [form ]
liquid
| [color ]
Colourless to Pale Yellow | [Stability:]
Stable. Combustible. Incompatible with water, alkalies, oxidizing agents. | [Water Solubility ]
Miscible with water. | [Sensitive ]
Moisture Sensitive | [Merck ]
14,3827 | [BRN ]
773969 | [InChIKey]
PLUBXMRUUVWRLT-UHFFFAOYSA-N | [CAS DataBase Reference]
62-50-0(CAS DataBase Reference) | [IARC]
2B (Vol. 7, Sup 7) 1987 | [NIST Chemistry Reference]
Methanesulfonic acid, ethyl ester(62-50-0) | [EPA Substance Registry System]
62-50-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R22:Harmful if swallowed.
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
2810 | [WGK Germany ]
3
| [RTECS ]
PB2100000
| [F ]
10-21 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29041000 | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic,
neoplas tigenic, tumorigenic, and teratogenic
data. Poison by ingestion and intraperitoneal
routes. Experimental reproductive effects.
Human mutation data reported. When
heated to decomposition it emits toxic
fumes of SOx. See also SULFONATES and
ESTERS. | [Hazardous Substances Data]
62-50-0(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
Clear colorless liquid. Denser than water. | [Reactivity Profile]
ETHYL METHANESULFONATE(62-50-0) alkylates nucleophiles such as hydroxy, amino and sulfhydryl groups in model and biological materials. Is hydrolyzed by excess aqueous alkali to non-corrosive and non-toxic products. Is hydrolyzed by water to a highly corrosive product . | [Air & Water Reactions]
Water soluble. | [Potential Exposure]
Used as a research tool for mutagenesis and carcinogenesis studies. Was considered as a possible
human male contraceptive. Also considered as a reversible
male hemosterilant for insects and mammalian pests.
| [Fire Hazard]
This chemical is combustible. | [First aid]
Skin Contact: Flood all areas of body that
have contacted the substance with water. Don’t wait to
remove contaminated clothing; do it under the water
stream. Use soap to help assure removal. Isolate contaminated clothing when removed to prevent contact by others.
Eye Contact: Remove any contact lenses at once. Flush
eyes well with copious quantities of water or normal saline
for a least 2030 minutes. Seek medical attention.
Inhalation: If convulsions are not present, give a glass or
two of water or milk to dilute the substance. Assure that
the person’s airway is unobstructed and contact a hospital
or poison center immediately for advice on whether or not
to induce vomiting. Ingestion: If convulsions are not present, give a glass or two of water or milk to dilute the substance. Assure that the person’s airway is unobstructed and
contact a hospital or poison center immediately for advice
on whether or not to induce vomiting eyes well with copious quantities of water or normal saline
for at least 2030 minutes. Seek medical attention.
Inhalation: Leave contaminated area immediately; breathe
fresh air. Proper respiratory protection must be supplied to
any rescuers. If coughing, difficult breathing or any other
symptoms develop, seek medical attention at once, even
if symptoms develop many hours after exposure. Ingestion:
If convulsions are not present, give a glass or two of water
or milk to dilute the substance. Assure that the person’s airway is unobstructed and contact a hospital or poison center
immediately for advice on whether or not to induce
vomiting | [Shipping]
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. Military driver shall be given full and
complete information regarding shipment and conditions in
case of emergency. AR 50-6 deals specifically with the
shipment of chemical agents. Shipments of agent will be
escorted in accordance with AR 740-32. | [Incompatibilities]
Vapors may form explosive mixture with
air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, and epoxides. Contact with moisture may cause
hydrolysis or other forms of decomposition | [Chemical Properties]
colourless liquid | [Chemical Properties]
Ethyl methane sulfonate is a clear liquid. | [Uses]
Ethyl methanesulfonate is used as mutagen for both mammalian and plant cells. It finds application as a model alkylating agent in the study of deoxyribonucleic acid (DNA) repair processes. | [Uses]
Experimentally as mutagen, teratogen and brain carcinogen. | [Definition]
ChEBI: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol. | [Biochem/physiol Actions]
Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana. | [Carcinogenicity]
Ethyl methanesulfonate is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. |
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