| Identification | More | [Name]
2-Bromoaniline | [CAS]
615-36-1 | [Synonyms]
1-Amino-2-bromobenzene
2-BROMOANILINE
2-bromobenzenamine
AKOS BBS-00003650
BROMOANILINE(2-)
O-BROMOANILINE
o-Chloroaceto-N-acetanilide
2-bromo-benzenamin
Aniline, o-bromo-
Benzenamine,2-bromo-
o-Aminobromobenzene
2-Bromoanilines
o-Bromoaniline 2-Bromoaniline
2-BROMOANILINE 99%
2-Bromoaniline,~98%
2-BROMO ANILINE FOR SYNTHESIS
2-Bromobenzeneamine
ORTHO-BROMOANILINE
2-Bromo-phenylamine
2-Amino-1-bromobenzene | [EINECS(EC#)]
210-421-3 | [Molecular Formula]
C6H6BrN | [MDL Number]
MFCD00007632 | [Molecular Weight]
172.02 | [MOL File]
615-36-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xn | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [F ]
8-23 | [Hazard Note ]
Toxic | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214210 |
| Questions And Answer | Back Directory | [Description]
O-bromoaniline, m-bromoaniline and p-bromoaniline corresponds to the three isomers of bromoaniline. All of them three are toxic with its toxicity being more severe than chloroanilines. It can be all via percutaneous absorption, being hemolytic and able to cause bladder cancer. It is mainly used for dye raw materials, such as azo dyes, quinazoline dyes and so on. Heating together with glycerol, concentrated sulfuric acid and o-bromonitrobenzene can generate 8-bromoquinoline.
The preparation of the three isomers is as follows:
- Take the corresponding nitroaniline as raw material, have it reacted with sodium nitrite in sulfuric acid, leading to the formation of diazonium salt, followed by reaction with hydrobromic acid under the action of cuprous bromide, leading to the formation of nitrobromobenzene, further subjecting to iron powder reaction in the bromic acid to generate the above three isomers.
- Take benzene as raw material, under the action of iron powder, have it reacted with bromine to generate bromobenzene. It is then reacted with mixed acid (the mixture of sulfuric acid and nitric acid) to generate o-nitrobenzene and p-nitro bromobenzene (orthoaccounts of 35%; paraaccounts of 65%), so that the two are separated, followed by the same process as method one to generate o-bromoaniline and p-bromoaniline.
- Take bromoacetanilide as raw material, put it into sodium hydroxide solution; apply water vapor reflux to obtain the bromoaniline.
| [Chemical Properties]
It appears as white needle crystal with a melting point of 32 ° C, boiling point of 229 ° C, 138-141 ° C (6.38-6.92 kPa), 110.5 ° C (2.53 kPa), relative density of 1.578 (20/4 ° C) and a refractive index of 1.6133. It is soluble in alcohol and ether, but can’t be dissolved in water.
| [Uses]
Organic synthesis intermediates
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