| Identification | More | [Name]
4-Nitro-1-naphthol | [CAS]
605-62-9 | [Synonyms]
1-HYDROXY-4-NITRONAPHTHALENE
4-NITRO-1-NAPHTHOL
4-Nitro-1-naphthol,99% | [EINECS(EC#)]
611-992-5 | [Molecular Formula]
C10H7NO3 | [MDL Number]
MFCD02179392 | [Molecular Weight]
189.17 | [MOL File]
605-62-9.mol |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2811 | [HazardClass ]
IRRITANT | [HS Code ]
29042090 |
| Hazard Information | Back Directory | [Uses]
KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC50s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases[1]. | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 30, p. 906, 1987 DOI: 10.1021/jm00388a027 | [storage]
4°C, stored under nitrogen | [References]
[1] Wapenaar H, et al. The relevance of Ki?calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. Eur J Med Chem. 2017 Aug 18;136:480-486. DOI:10.1016/j.ejmech.2017.05.015 |
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