| Identification | More | [Name]
Semicarbazide hydrochloride | [CAS]
563-41-7 | [Synonyms]
AMINOUREA HYDROCHLORIDE
CARBAMIC ACID HYDRAZIDE HYDROCHLORIDE
CARBAMYLHYDRAZINE HYDROCHLORIDE
HYDRAZINE CARBOXAMIDE HYDROCHLORIDE
HYDRAZINE CARBOXAMIDE MONOHYDROCHLORIDE
N-AMINOUREA HYDROCHLORIDE
SEMICARBAZIDE CHLORHYDRATE
SEMICARBAZIDE HCL
SEMICARBAZIDE HYDROCHLORIDE
amidoureahydrochloride
semicarbazide,monohydrochloride
semicarbazidechloride
ammourea hydrochloride
Semikarbazide hydrochloride.
SEMICARBAZIDE HYDROCHLORIDE, FOR ANALY-T ICAL PURPOSES
SEMICARBAZIDE HYDROCHLORIDE, 99+%
SEMICARBAZIDE HYDROCHLORIDE R. G.
SEMICARBAZIDE HYDROCHLORIDE GR 99.5+%
SemicarbazideHydrochlorideA.R.
SemicarbazideHydrochlorideGr | [EINECS(EC#)]
209-247-0 | [Molecular Formula]
CH6ClN3O | [MDL Number]
MFCD00013009 | [Molecular Weight]
111.53 | [MOL File]
563-41-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Semicarbazide hydrochloride is a white crystalline solid. | [Melting point ]
175-177 °C (dec.)(lit.)
| [Boiling point ]
394.09℃[at 101 325 Pa] | [density ]
1.2908 (rough estimate) | [vapor pressure ]
0-0Pa at 25℃ | [refractive index ]
1.4480 (estimate) | [storage temp. ]
Store at +15°C to +25°C. | [solubility ]
H2O: 0.1 g/mL at 20 °C, clear, colorless
| [form ]
Crystalline Powder and/or Chunks | [color ]
White | [PH]
1.5 (100g/l, H2O, 20℃) | [Stability:]
Stable. Incompatible with strong oxidizing agents, strong bases. | [Water Solubility ]
100 g/L (15 ºC) | [Usage]
Inhibitor of enzyme. Hypotensive | [Merck ]
14,8444 | [BRN ]
3593642 | [InChIKey]
XHQYBDSXTDXSHY-UHFFFAOYSA-N | [LogP]
-4.99--1.9 at 20℃ | [CAS DataBase Reference]
563-41-7(CAS DataBase Reference) | [IARC]
3 (Vol. 12, Sup 7) 1987 | [EPA Substance Registry System]
563-41-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T | [Risk Statements ]
R22:Harmful if swallowed.
R40:Limited evidence of a carcinogenic effect.
R36/38:Irritating to eyes and skin .
R25:Toxic if swallowed.
R45:May cause cancer.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S53:Avoid exposure-obtain special instruction before use . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
VT3500000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29280000 | [Safety Profile]
Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and teratogenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl | [Hazardous Substances Data]
563-41-7(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 123 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Hydrazinium hydroxide solution-->Hydrazine hydrate-->Semicarbazide | [Preparation Products]
Semicarbazide-->4-CHLORO-2-(TETRAHYDRO-2H-PYRAN-2-YL)-5-HYDROXYPYRIDAZIN-3(2H)-ONE-->3-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE-->5-CHLORO-4-(CHLOROMETHYL)-1,2,3-THIADIAZOLE, 97%, 97-->3-Amino-5-phenylpyrazole-->3-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE-->ETHYL 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLATE-->4,5-Dichloro-3(2H)-pyridazinone-->6-AZATHYMINE-->Carbazochrome-->5-Chloromethyl-2H-1,2,4-triazolin-3-one-->ethyl 5-oxo-2,5-dihydro-1H-pyrazole-3-carboxylate-->naftazone-->1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one-->5-[2-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-amine-->Aminoacetonesemicarbazonehydrochloride-->5-(2-BROMOPHENYL)-1,3,4-OXADIAZOL-2-AMINE |
| Hazard Information | Back Directory | [Hazard]
Toxic by ingestion. Questionable carcino-
gen.
| [Potential Exposure]
This material is used as a reagent for ketones and aldehydes with which it affords crystalline compounds having characteristic freezing/melting points. Also used in isolation of hormones and certain fractions from essential oils. | [First aid]
Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24 to 48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy. | [Shipping]
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. | [Incompatibilities]
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May ignite combustible materials (wood, oil, paper). | [Chemical Properties]
Semicarbazide hydrochloride is a white crystalline solid. | [Chemical Properties]
White Solid | [Uses]
A metabolite of Nitrofuran. | [Uses]
Inhibitor of enzyme. Hypotensive | [Definition]
ChEBI: Semicarbazide hydrochloride is an organic molecular entity. | [Health Hazard]
Semicarbazide hydrochloride is a chemical reagent, and an indicator for its metabolic parent nitrofurazone, a veterinary drug that has been banned for use in livestock production in the European Union and the U.S. amongst other jurisdictions.
After Semicarbazide hydrochloride ingestion, experimental animals have developed tremors, ataxia, equilibrium difficulties, and convulsions. Its proposed mechanism of action is by binding to cytosine residues in RNA, to deoxycytosine residues in DNA and to cytosine and deoxycytosine nucleosides.
Semicarbazide hydrochloride has an oral LD50 of 225mg/kg in mice and 123 mg/kg in the rat. Some studies suggest that Semicarbazide hydrochloride is a mutagen, an animal carcinogen and a teratogen.
Due to the lack of data in humans and overall limited evidence of carcinogenicity in animals, semicarbazide hydrochloride was classified as an IARC Group 3 agent: not classifiable as to its carcinogenicity to humans. Due to its equivocal carcinogenic and mutagenic properties, when handling Semicarbazide hydrochloride and animals treated with Semicarbazide hydrochloride, it is imperative to take caution and adhere to the following guidelines to minimize exposure and the effects of exposure during normal and emergency situations. | [Flammability and Explosibility]
Notclassified | [Purification Methods]
Crystallise the salt from aqueous 75% EtOH and dry it under vacuum over CaSO4. Alternatively crystallise it from a mixture of 3.6 mole % MeOH and 6.4 mole % of water. [Kovach et al. J Am Chem Soc 107 7360 1985.] IR: 700, 3500 cm-1 [Ingersoll et al. Org Synth Coll Vol I 485 1941, Davison & Christie J Chem Soc 3389 1955, Thiele & Stange Chem Ber 27 33 1894, pK: Bartlett J Am Chem Soc 54 2853 1923]. The free base crystallises as prisms from absolute EtOH, m 96o. [Curtius & Heidenreich Chem Ber 27 55 1894, Beilstein 3 IV 177.] TOXIC ORALLY, possible CARCINOGEN and TERATOGEN. |
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