| Identification | More | [Name]
AMINOGUANIDINE HYDROCHLORIDE | [CAS]
1937-19-5 | [Synonyms]
amino-guanidinhydrochloride
hydrazinecarboximidamidehydrochloride
carbazamidine monohydrochloride
AMINOGUANIDINE HYDROCHLORIDE, 98+%
Aminoguanidine HCL
AMINOGUANIDINE SALT
GUANYLHYDRAZINEHCL
GUANIDINE,AMINO-,MONOHYDROCHLORIDE
Aminoguanidine hydrochoride
1-Aminoguanidine·hydrochloride
Aminoguanidine salts | [EINECS(EC#)]
217-707-7 | [Molecular Formula]
CH7ClN4 | [MDL Number]
MFCD00039074 | [Molecular Weight]
110.546 | [MOL File]
1937-19-5.mol |
| Questions And Answer | Back Directory | [Uses]
Aminoguanidine Hydrochloride is used in the synthetic preparation of highly selective and potent G-protein-coupled receptor kinase 2 (GRK2) inhibitor for potential treatment of heart failure. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
ME8430000
| [F ]
10-21 | [HS Code ]
29280000 |
| Hazard Information | Back Directory | [Description]
Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS.1,2 The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 μM, respectively.2 Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.3 | [Chemical Properties]
white to off-white crystals | [General Description]
Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar. | [Flammability and Explosibility]
Notclassified | [Biochem/physiol Actions]
Inhibits both constitutive and inducible nitric oxide synthetase. |
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