| Identification | More | [Name]
N-Succinimidyl 6-maleimidohexanoate | [CAS]
55750-63-5 | [Synonyms]
6-MALEIMIDOCAPROIC ACID N-SUCCINIMIDYL ESTER
EMCS
EPSILON-MALEIMIDOCAPROIC ACID N-HYDROXYSUCCINIMIDE ESTER
N-(6-MALEIMIDOCAPROYLOXY)SUCCINIMIDE
N-(E-MALEIMIDOCAPROYLOXY)SUCCINIMIDE
N-(EPSILON-MALEIMIDOCAPROYLOXY)SUCCINIMIDE
N-[EPSILON-MALEIMIDOCAPROYLOXY]SUCCINIMIDE ESTER
N-SUCCINIMIDYL 6-MALEIMIDOCAPROATE
N-SUCCINIMIDYL 6-MALEIMIDOHEXANOATE
6-Maleimidohexanoic acid N-hydroxysuccinimide ester
N-SUCCINIMIDYL-6-MALEMIDOCAPROATE, 99%
EPISILON-MALEIMIDOCAPROIC ACID N-*HYDROX YSUCCINIMID
6-maleimidohexanoic acid n-succinimidyl ester
N-(6-Maleimidocaproyloxy)succinimideN-Succinimidyl-6-maleimidohexanoate
6-Maleimidocaproic acid N-hydroxysuccinimide ester
N-Succinimidyl 6-Maleimidohexanoate [Cross-linking Reagent]
6-Maleimidocaproic acid N-succinimidyl ester, N-(ε-Maleimidocaproyloxy)succinimide, N-Succinimidyl 6-maleimidocaproate, EMCS
6-Maleimidohexanoic acid N-hydroxy succinimidyl ester | [EINECS(EC#)]
637-238-5 | [Molecular Formula]
C14H16N2O6 | [MDL Number]
MFCD00043043 | [Molecular Weight]
308.29 | [MOL File]
55750-63-5.mol |
| Chemical Properties | Back Directory | [Appearance]
White to cream colored crystals | [Melting point ]
70-73 °C(lit.)
| [Boiling point ]
480.6±47.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
chloroform: 100mg/mL
| [form ]
powder
| [pka]
-2.21±0.20(Predicted) | [color ]
Off-white to pale brown | [Sensitive ]
Light & Moisture Sensitive & Hygroscopic | [BRN ]
1499815 | [InChI]
InChI=1S/C14H16N2O6/c17-10-5-6-11(18)15(10)9-3-1-2-4-14(21)22-16-12(19)7-8-13(16)20/h5-6H,1-4,7-9H2 | [InChIKey]
VLARLSIGSPVYHX-UHFFFAOYSA-N | [SMILES]
N1(CCCCCC(ON2C(=O)CCC2=O)=O)C(=O)C=CC1=O | [CAS DataBase Reference]
55750-63-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
8-10-21 | [HS Code ]
29280000 |
| Hazard Information | Back Directory | [Description]
Mal-heptanoic NHS ester contains a maleimide group and an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | [Chemical Properties]
White to cream colored crystals | [Uses]
6-Maleimidohexanoic acid N-hydroxysuccinimide ester can be used in:
- Synthesis of maleimide-activated carbohydrates for site-specific glycosylation of cysteine-containing peptides and proteins via maleimide-thiol ligation reaction.
- Synthesis of a glucuronide prodrug of doxorubicin bearing a maleimide side chain as an antitumor agent.
- Cross-linking oligonucleotides with the amino groups on the substrate to fabricate DNA microarrays.
| [reaction suitability]
reagent type: linker |
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