| Identification | More | [Name]
Maleimide | [CAS]
541-59-3 | [Synonyms]
1h-pyrrole-2,5-dione
2,5-PYRROLEDIONE
ASISCHEM S97810
MALEIC ACID IMIDE
MALEIMIDE
PYRROLE-2,5-DIONE
3-Pyrroline-2,5-dione
Maleic imide
maleicimide
Maleinimide
2,5-Dioxo-3-pyrroline~1H-Pyrrole-2,5-dione
Maleimide, 98+%
2,5-dioxo-3-pyrroline
1H-Pyrrole-2,5-dione,2,5-Pyrroledione | [EINECS(EC#)]
208-787-4 | [Molecular Formula]
C4H3NO2 | [MDL Number]
MFCD00005494 | [Molecular Weight]
97.07 | [MOL File]
541-59-3.mol |
| Chemical Properties | Back Directory | [Appearance]
slight yellow crystalline powder | [Melting point ]
91-93 °C (lit.) | [Boiling point ]
97-103°C 5mm | [density ]
1,2493 g/cm3 | [refractive index ]
1.4543 (estimate) | [Fp ]
97-103°C/5mm | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
soluble in Methanol | [form ]
Fine Crystalline Powder | [pka]
8.52±0.20(Predicted) | [color ]
White to slightly yellow | [Water Solubility ]
SOLUBLE | [λmax]
280nm(EtOH)(lit.) | [BRN ]
106910 | [InChIKey]
PEEHTFAAVSWFBL-UHFFFAOYSA-N | [CAS DataBase Reference]
541-59-3(CAS DataBase Reference) | [NIST Chemistry Reference]
1H-pyrrole-2,5-dione(541-59-3) | [EPA Substance Registry System]
541-59-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,C | [Risk Statements ]
R25:Toxic if swallowed.
R34:Causes burns.
R43:May cause sensitization by skin contact.
R36/37/38:Irritating to eyes, respiratory system and skin .
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37/39:Wear suitable gloves and eye/face protection .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 2923 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
ON4800000
| [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29251995 | [Safety Profile]
Poison by
intraperitoneal and intravenous routes. An
experimental teratogen. Experimental
reproductive effects. When heated to
decomposition it emits toxic fumes of NOx. |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Potassium dichromate-->Fiber Glass Wool-->4-Maleimidophenol | [Preparation Products]
N-(2-AMINOETHYL)MALEIMIDE TRIFLUOROACETA-->4-MALEIMIDOBUTYRIC ACID-->N-METHOXYCARBONYLMALEIMIDE-->CIS-5-BENZYLTETRAHYDROPYRROLO[3,4-C]PYRROLE-1,3(2H,3AH)-DIONE-->1,5-DIHYDRO-PYRROL-2-ONE-->N-METHYLSUCCINIMIDE-->N-MALEIMIDOMETHANOL-->3-(2-Chloro-phenyl)-pyrrole-2,5-dione-->1,2,3,4-CyclobutanetetracarboxdiiMide-->3-(4-Bromo-phenyl)-pyrrole-2,5-dione-->2-Methyl-3-methylsulfanyl-4-phenyl-3,5-dihydro-2H-pyrrolo[3,4-c]pyridine-1,6-dione-->3-(1H-indol-3-yl)pyrrolidine-2,5-dione-->CarbaMic acid, [5-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)pentyl]-, 1,1-diMethylethyl ester-->(1R,5S)-6,6-diMethyl-3-azabicyclo[3.1.0]hexane-2,4-dione |
| Hazard Information | Back Directory | [Hazard]
A poison. | [Chemical Properties]
slight yellow crystalline powder | [Uses]
Rhodium-catalyzed conjugate arylation with arylboronic acids.1 | [Definition]
ChEBI: A cyclic dicarboximide in which the two carboacyl groups on nitrogen together with the nitogen itself form a 1H-pyrrole-2,5-dione structure. | [General Description]
Maleimide (2,5-Pyrroledione) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions. | [Purification Methods]
Purify it by sublimation in a vacuum. The UV has max at 216 and 280nm in EtOH. [de Wolf & van de Straete Bull Soc Chim Belg 44 288 1935, UV: Rondestvedt et al. J Am Chem Soc 78 6115 1956, IR: Chiorboli & Mirone Ann Chim (Rome) 42 681 1952, Beilstein 21/10 V 3.] |
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