Identification | More | [Name]
Tangeretin | [CAS]
481-53-8 | [Synonyms]
4',5,6,7,8-PENTAMETHOXYFLAVONE 5,6,7,8,4'-PENTAMETHOXYFLAVONE 5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4-benzopyrone TANGERETIN TANGERITIN 2-(4-methoxyphenyl)-5,6,7,8-tetramethoxy-4h-1-benzopyran-4-on 2-(4-methoxyphenyl)-5,6,7,8-tetramethoxy-4h-1-benzopyran-4-one 4’,5,6,7,8-pentamethoxy-flavon Flavone, 5,6,7,8,4'-pentamethoxy ponkanetin TANGERETIN(P) TANGERETIN(RG) TANGARETIN TANGERETIN, NATURAL 2-(4-methoxyphenyl)- 4H-1-Benzopyran-4-one,5,6,7,8-tetramethoxy- 5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one Tangeritine | [EINECS(EC#)]
207-570-1 | [Molecular Formula]
C20H20O7 | [MDL Number]
MFCD00017438 | [Molecular Weight]
372.37 | [MOL File]
481-53-8.mol |
Safety Data | Back Directory | [Hazard Codes ]
T,Xi | [Risk Statements ]
R25:Toxic if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S36:Wear suitable protective clothing . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 2811 | [WGK Germany ]
3 | [RTECS ]
DJ3102725 | [HS Code ]
29329990 | [Toxicity]
rat,LD50,intraperitoneal,> 1gm/kg (1000mg/kg),Advances in Teratology. Vol. 3, Pg. 181, 1968. |
Hazard Information | Back Directory | [Chemical Properties]
Yellow powder | [Uses]
Tangeretin[481-53-8] has been used as an antioxidant and antifungal agent to test its effects on ferroptosis inhibition, conidial development, and appressorium formation against Magnaporthe oryzae. It has also been used as a co-chemotherapeutics agent to study its cytotoxic effects in combination with 5-Fluorouracil (5-Fu) on WiDr colon cancer cells. | [Definition]
ChEBI: Tangeretin is a pentamethoxyflavone flavone with methoxy groups at positions 4', 5, 6 , 7 and 8. It has a role as an antineoplastic agent and a plant metabolite. | [General Description]
Tangeretin is a polymethoxyflavone extracted primarily from the peels of citrus fruits like Citrus sinensis and Citrus reticulata. | [Biological Activity]
Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication and to inhibit cell proliferation in several cancer lines. | [References]
[1] K. AGRAWAL Y. M. Tangeretin: A Biologically Potential Citrus Flavone[J]. Current Traditional Medicine, 2022. DOI:10.2174/2215083808666220304100702. [2] JUHEE SEO . Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activation[J]. European journal of pharmacology, 2011, 673 1: Pages 56-64. DOI:10.1016/j.ejphar.2011.10.011. [3] Z CHENG. Tangeretin and its metabolite 4′-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K[J]. British Journal of Pharmacology, 2010, 162 8: 1781-1791. DOI:10.1111/j.1476-5381.2010.01185.x. [4] GUY LEWIN*. Semisynthesis of Natural Flavones Inhibiting Tubulin Polymerization, from Hesperidin[J]. Journal of Natural Products , 2010, 73 4: 702-706. DOI:10.1021/np100065v. [5] WASEEM RAZA Abha M Suaib Luqman. Prospects of tangeretin as a modulator of cancer targets/pathways[J]. Pharmacological research, 2020, 161: Article 105202. DOI:10.1016/j.phrs.2020.105202. |
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