| Identification | More | [Name]
4-Methoxybenzylchloride | [CAS]
824-94-2 | [Synonyms]
1-CHLOROMETHYL-4-METHOXYBENZENE
4-(CHLOROMETHYL)ANISOL
4-(CHLOROMETHYL)ANISOLE
4-METHOXYBENZYL CHLORIDE
AKOS BBS-00003861
ANISYL CHLORIDE
METHOXYBENZYLCHLORIDE(P-)
P-METHOXYBENZYL CHLORIDE
alpha-Chloro-4-methoxytoluene
Anisole, p-(chloromethyl)-
Benzene, 1-(chloromethyl)-4-methoxy-
p-(Chloromethyl)anisole
p-Anisyl chloride
P-methoxyl benzylchloride
4-Methoxybenzylchloride99%
4-Methoxybenzylchloride 99%
4-Methoxybenzene methyl chloride
α-Chloro-4-methoxytoluene
4-Methoxybenzylchloride, stabilized, 98%
4-METHOXYBENZYL CHLORIDE (STABILIZED WITH CALCIUM CARBONATE) | [EINECS(EC#)]
212-540-6 | [Molecular Formula]
C8H9ClO | [MDL Number]
MFCD00000915 | [Molecular Weight]
156.61 | [MOL File]
824-94-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless liquid | [Melting point ]
−1 °C(lit.)
| [Boiling point ]
117-118 °C14 mm Hg(lit.)
| [density ]
1.155 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.548(lit.)
| [Fp ]
229 °F
| [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Liquid | [color ]
Clear colorless to pale yellow | [Water Solubility ]
slowly decomposes | [Stability:]
Moisture Sensitive | [InChIKey]
MOHYOXXOKFQHDC-UHFFFAOYSA-N | [CAS DataBase Reference]
824-94-2(CAS DataBase Reference) | [NIST Chemistry Reference]
«alpha»-Chloro-4-methoxytoluene(824-94-2) | [Storage Precautions]
Store under inert gas |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 3
| [WGK Germany ]
3
| [F ]
10-19-21 | [Autoignition Temperature]
109℃ | [Hazard Note ]
Corrosive | [TSCA ]
No | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29093090 |
| Raw materials And Preparation Products | Back Directory | [Preparation Products]
4-Methoxybenzyl cyanide-->1-(4-METHOXYBENZYL)PIPERAZINE-->1,6:2,3-Dianhydro-β-D-mannopyranose-->H-BETA,BETA-DIMETHYL-L-CYS(PMEOBZL)-OH-->4-METHOXYBENZYLMAGNESIUM CHLORIDE-->4(3H)-Pyrimidinone, 5-bromo-6-(difluoromethyl)-3-[(4-methoxyphenyl)methyl]--->1-(4-METHOXYBENZYL)-1H-INDOLE-2,3-DIONE-->Methyl 1-[(4-methoxyphenyl)methyl]-1H-indazole-3-carboxylate-->2-Propenoic acid, (4-methoxyphenyl)methyl ester-->3-bromo-6-((4-methoxybenzyl)oxy)benzaldehyde-->Carbamimidothioicacid, (4-methoxyphenyl)methyl ester, hydrochloride (1:1)-->2-Pyrimidinamine, 5-bromo-N,N-bis[(4-methoxyphenyl)methyl]--->Benzaldehyde, 2-[(4-methoxyphenyl)methoxy]- |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless liquid | [Uses]
O/N protecting group reagent which can be mildly oxidatively cleaved, e.g., with ceric ammonium nitrate. | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 20, p. 190, 1977 DOI: 10.1021/jm00212a002
The Journal of Organic Chemistry, 53, p. 3634, 1988 DOI: 10.1021/jo00250a048 | [General Description]
4-Methoxybenzyl chloride undergoes mild oxidative claevage with ceric ammonium nitrate. | [Purification Methods]
Purify 4-anisyl chloride by fractional distillation under vacuum, and the middle fraction is redistilled at 10-6 mm at room temperature by intermittent cooling of the receiver in liquid N2, and the middle fraction is collected. [Mohammed & Kosower J Am Chem Soc 93 2709 1971, Beilstein 6 IV 2137.] |
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