| Identification | More | [Name]
Procarbazine hydrochloride | [CAS]
366-70-1 | [Synonyms]
n-(1-methylethyl)-4-((2-methylhydrazino)methyl)benzamide hydrochloride
PROCARBAZINE HCL
PROCARBAZINE HYDROCHLORIDE
1-(p-isopropylcarbamoylbenzyl)-2-methylhydrazinehydrochloride
1-methyl-2-(p-isopropylcarbamoylbenzyl)hydrazinehydrochloride
1-methyl-2-p-(isopropylcarbamyol)benzohydrazinehydrochloride
2-(p-(isopropylcarbamoyl)benzyl)-1-methylhydrazinehydrochloride
chlorhydratede1-methyl2p(isopropylcarbamoyl)benzyl-hydrazine
ibenzmethyzinehydrochloride
ibenzmethyzinhydrochloride
ibz
matulane
n-(1-methylethyl)-4-((2-methylhydrazino)methyl)-benzamidmonohydrochlorid
natulanhydrochloride
nci-c01810
n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidehydrochloride
n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidhydrochloride
n-isopropyl-alpha-(2-methylhydrazino)-p-toluamidmonohydrochloride
n-isopropyl-p-(2-methylhydrazinomethyl)benzamidehydrochloride
nsc-77213 | [EINECS(EC#)]
206-678-6 | [Molecular Formula]
C12H20ClN3O | [MDL Number]
MFCD00072082 | [Molecular Weight]
257.76 | [MOL File]
366-70-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Procarbazine is a white to pale yellow crystal-
line powder with a slight odor. | [Melting point ]
223°C | [density ]
8.3 g/cm3 | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO: ≥18mg/mL | [form ]
powder | [color ]
white to tan | [Water Solubility ]
>=10 g/100 mL at 21.5 ºC | [Usage]
Antineoplastic | [Merck ]
14,7758 | [BCS Class]
3/1 | [CAS DataBase Reference]
366-70-1(CAS DataBase Reference) | [IARC]
2A (Vol. 26, Sup 7) 1987 | [EPA Substance Registry System]
366-70-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
45-61-22-68 | [Safety Statements ]
53-36/37-45 | [WGK Germany ]
3 | [RTECS ]
XS4725000 | [HS Code ]
2928002500 | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic, and teratogenic
data. Poison by an unspecified route.
Moderately toxic by ingestion,
subcutaneous, intravenous, and
intraperitoneal routes. Experimental
reproductive effects. Mutation data
reported. When heated to decomposition it
emits very toxic fumes of NOx and HCl.
Used as a chemotherapeutic agent. | [Toxicity]
LD50 orally in rats: 785 ±34 mg/kg (Goldenthal) |
| Hazard Information | Back Directory | [General Description]
White to pale yellow crystalline powder with a slight odor. Acid to litmus. | [Reactivity Profile]
PROCARBAZINE HYDROCHLORIDE(366-70-1) is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media . | [Air & Water Reactions]
In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble. | [Potential Exposure]
Procarbazine is available in capsule
form. The primary use of this drug is as an antineoplastic
agent in the treatment of advanced Hodgkin’s disease, and
oat-cell carcinoma of the lung. The hydrochloride com-
pound is used in treatment. The FDA approved use of pro-
carbazine hydrochloride in 1969 and indicated that the drug
should be used as an adjunct to standard therapy. Possible
exposure occurs during manufacture of the drug and direct
exposure during its subsequent administration to patients.
Some of the metabolites of procarbazine hydrochloride are
both carcinostatic and carcinogenic. | [Fire Hazard]
Flash point data for this chemical are not available; however, PROCARBAZINE HYDROCHLORIDE is probably combustible. | [First aid]
Move victim to fresh air. Call 911 or emergency
medical service. Give artificial respiration if victim is not
breathing. Do not use mouth-to-mouth method if victim
ingested or inhaled the substance; give artificial respira-
tion with the aid of a pocket mask equipped with a one-way
valve or other proper respiratory medical device.
Administer oxygen if breathing is difficult. Remove and
isolate contaminated clothing and shoes. In case of contact
with substance, immediately flush skin or eyes with run-
ning water for at least 20 minutes. For minor skin contact,
avoid spreading material on unaffected skin. Keep victim
warm and quiet. Effects of exposure (inhalation, ingestion
or skin contact) to substance may be delayed. Ensure that
medical personnel are aware of the material(s) involved
and take precautions to protect themselves. Medical obser-
vation is recommended for 24?48 hours after breathing
overexposure, as pulmonary edema may be delayed.
As first aid for pulmonary edema, a doctor or authorized
paramedic may consider administering a drug or other
inhalation therapy. | [Shipping]
UN2811 Toxic solids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. | [Incompatibilities]
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or
explosions. Keep away from alkaline materials, strong
bases, strong acids, oxoacids, epoxides. | [Chemical Properties]
Crystalline Solid | [Chemical Properties]
Procarbazine is a white to pale yellow crystal-
line powder with a slight odor. | [Waste Disposal]
It is inappropriate and
possibly dangerous to the environment to dispose of
expired or waste drugs and pharmaceuticals by flushing
them down the toilet or discarding them to the trash.
Household quantities of expired or waste pharmaceuticals
may be mixed with wet cat litter or coffee grounds,
double-bagged in plastic, discard in trash. Larger quanti-
ties shall carefully take into consideration applicable
DEA, EPA, and FDA regulations. If possible return the
pharmaceutical to the manufacturer for proper disposal
being careful to properly label and securely package
the material. Alternatively, the waste pharmaceutical
shall be labeled, securely packaged and transported by a
state licensed medical waste contractor to dispose by
burial in a licensed hazardous or toxic waste landfill
or incinerator. | [Uses]
Antineoplastic. | [Uses]
Antineoplastic;DNA replication inhibitor | [Uses]
Procarbazine hydrochloride USP is used to traet Hodgkin’s disease; non-Hodgkin’s lymphomas; lung cancer. | [Definition]
ChEBI: A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaki
g of DNA strands. | [Brand name]
Matulane (Sigma-Tau). | [Veterinary Drugs and Treatments]
In veterinary medicine, procarbazine is used as part of MOPP protocols
(mechlorethamine, vincristine, procarbazine, prednisone) to
treat lymphomas in dogs and cats. It may be of benefit in treating
granulomatous meningoencephalitis (GME) in dogs. |
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