| Identification | More | [Name]
1-Bromo-2,4-difluorobenzene | [CAS]
348-57-2 | [Synonyms]
1-BROMO-2,4-DIFLUOROBENZENE
2,4-DIFLUOROBROMOBENZENE
2,4-Difluoro-1-bromobenzene
Bromo-2,4-difluorobenzene
1-Bromo-2,4-difluorobenzene, 98+%
2,4-Difluoro
1-Bromo-2,4-difluorobenzene,min.98%
Benzene, 1-bromo-2,4-difluoro-
1-Bromo-2,4-difluorobenzene 99%
1-Bromo-2,4-difluorobenzene99%
1-BROMO-2,4-DIFLUOROBENZENEFLOCONAZOLE
1-BROMO-2-4-DIFLUOROBENZENE pure
2,4-Difluorophenyl bromide
4-Bromo-1,3-difluorobenzene
1-Bromo-2,4-difluorobenzene, min. 98% | [EINECS(EC#)]
206-479-4 | [Molecular Formula]
C6H3BrF2 | [MDL Number]
MFCD00000330 | [Molecular Weight]
192.99 | [MOL File]
348-57-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless to brown liqui | [Melting point ]
-4 °C (lit.) | [Boiling point ]
145-146 °C (lit.) | [density ]
1.708 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.505(lit.)
| [Fp ]
125 °F
| [storage temp. ]
2-8°C
| [form ]
Liquid | [color ]
Clear colorless to brown | [Specific Gravity]
1.708 | [PH]
5.02 at 24℃ and 10g/L | [Water Solubility ]
INSOLUBLE | [BRN ]
1680892 | [InChIKey]
MGHBDQZXPCTTIH-UHFFFAOYSA-N | [CAS DataBase Reference]
348-57-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzene, 1-bromo-2,4-difluoro-(348-57-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,F | [Risk Statements ]
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [Hazard Note ]
Flammable | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29036990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Carbon tetrachloride-->1,3-Difluorobenzene-->(2,4-DIFLUOROPHENYL)TRIMETHYLSILANE-->Bromoacetonitrile | [Preparation Products]
Fluconazole-->2,4-Difluorophenylboronic acid-->4-Bromo-3-fluorophenol-->2',4'-Difluoroacetophenone-->3-BROMO-2,6-DIFLUOROBENZALDEHYDE-->MK8245-->1-(5-Bromo-2,4-difluoro-phenyl)-ethanone-->3-bromo-2,6-difluorobenzoic acid-->(2R,3R)-2-(2,4-difluorophenyl)-3-(tetrahydro-2H-pyran-2-yloxy)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol-->DIETHYL 2,4-DIFLUOROPHENYL MALONATE |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to brown liqui | [Uses]
1-Bromo-2,4-difluorobenzene has been used in:
- preparation of (2S)-1-(2,4-difluorophenyl)-2-(1,1-dimethyl-1-sila-ethoxy)-propan-1-one
- enantiomeric preparation of the key intermediate of chiral azole antifungal agents by a chemoenzymatic process
| [General Description]
1-Bromo-2,4-difluorobenzene undergoes lithiation exclusively at the position having two adjacent halogen substituents, to yield 6-bromo-2,3-difluorobenzoic acid. |
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