| Chemical Properties | Back Directory | [Boiling point ]
517.1±50.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [pka]
11.95±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
TCO-PEG4-amine is a heterobifunctional click chemistry reagent. Amine is very reactive with active NHS ester or with carboxylic acid in the presence of of activators suh as EDC. TCO moiety enable fast click chemistry with tetrazine molecule. | [Uses]
TCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001 |
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