| Identification | Back Directory | [Name]
trans-Cyclooctene-maleimide | [CAS]
1609659-01-9 | [Synonyms]
TCO-PEG3-maleimide
(4E)-TCO-PEG3-Maleimide
trans-Cyclooctene-maleimide
Trans-Cyclooctene-PEG3-Maleimide,TCO-PEG3-Maleimide
6,9,12-Trioxa-2,16-diazanonadecanoic acid, 19-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-17-oxo-, 4-cycloocten-1-yl ester | [Molecular Formula]
C26H41N3O8 | [MDL Number]
MFCD28053553 | [MOL File]
1609659-01-9.mol | [Molecular Weight]
523.62 |
| Chemical Properties | Back Directory | [Boiling point ]
717.1±60.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
liquid | [pka]
12.38±0.46(Predicted) |
| Hazard Information | Back Directory | [reaction suitability]
reaction type: click chemistry
reagent type: linker | [Biochem/physiol Actions]
Maleimide (thiol reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into thiol containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1; 2; 4; 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility; less aggregation and an increased distance between the thiol to be modified and the reactive alkene. |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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