| Identification | Back Directory | [Name]
TCO-carbonate | [CAS]
1191901-33-3 | [Synonyms]
TCO-NHS
TCO-NHS ester
TCO-carbonate
(4E)-TCO-NHS ester
1191901-33-3(Mixture)
TCO4 - NHS carbonate / AXIAL isomer
TCO-N-hydroxysuccinimidyl carbonate
TCO4 - NHS carbonate / EQUATORIAL isomer
TCO-NHS Ester,Trans-Cyclooctene-NHS ester
(E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate
trans-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl carbonate
(E)-4-Cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl ester carbonic acid
Carbonic acid, (4E)-4-cycloocten-1-yl 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C13H17NO5 | [MDL Number]
MFCD24386372 | [MOL File]
1191901-33-3.mol | [Molecular Weight]
267.28 |
| Chemical Properties | Back Directory | [Melting point ]
90-105°C | [Boiling point ]
369.1±45.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white | [InChI]
InChI=1S/C13H17NO5/c15-11-8-9-12(16)14(11)19-13(17)18-10-6-4-2-1-3-5-7-10/h1-2,10H,3-9H2/b2-1+ | [InChIKey]
OUGQJOKGFAIFAQ-OWOJBTEDSA-N | [SMILES]
C(ON1C(=O)CCC1=O)(=O)OC1CCCC=CCC1 |t:16| |
| Hazard Information | Back Directory | [Description]
TCO-NHS Ester is an popular reagent to label amine-containing compound or biomolecule, TCOI enable fast click chemistry with tetrazine. | [Uses]
Succinimidyl carbonate/NHS functionalized cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging. | [reaction suitability]
reaction type: click chemistry
reagent type: linker | [IC 50]
Alkyl/ether |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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