| Identification | More | [Name]
2-Bromobiphenyl | [CAS]
2052-07-5 | [Synonyms]
1,1'-BIPHENYL, 2-BROMO-
2-bromo-1,1'-biphenyl
2-BROMOBIPHENYL
2-BROMODIPHENYL
BROMOBIPHENYL(2-)
PBB NO 1
2-bromo-1’-biphenyl
Biphenyl, 2-bromo-
o-Bromobiphenyl
2-Brombiphenyl
pbb 1
2-BROMOBIPHENYL 98.0+%
2-Biphenylyl bromide
2-Phenylbromobenzene
Biphenyl-2-yl bromide | [EINECS(EC#)]
218-141-3 | [Molecular Formula]
C12H9Br | [MDL Number]
MFCD00000065 | [Molecular Weight]
233.1 | [MOL File]
2052-07-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Liquid | [Melting point ]
1.5-2 °C(lit.)
| [Boiling point ]
297-298 °C(lit.)
| [density ]
1.352 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.628(lit.)
| [Fp ]
113 °C
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Sparingly, Heated), Methanol (Slightly) | [form ]
Liquid | [color ]
Clear colorless | [Specific Gravity]
1.352 | [Stability:]
Stable, but light sensitive. Incompatible with strong oxidizing agents. | [Water Solubility ]
Insoluble | [BRN ]
1863156 | [CAS DataBase Reference]
2052-07-5(CAS DataBase Reference) | [NIST Chemistry Reference]
| [EPA Substance Registry System]
2052-07-5(EPA Substance) |
| Questions And Answer | Back Directory | [Description]
2-Bromobiphenyl is an important intermediate, which can be used to synthesize 2,2'-dibromo-9,9'-spirobifluorene, 3-bromo-9-(9-phenylfluoren-9-yl)carbazole and phenanthrene compounds. | [Uses]
2-Bromobiphenyl can be used as reference compound to investigate extraction efficiency of solid-phase microextraction fibers, based on methacrylic acid-trimethylolpropanetrimethacrylate copolymers.
| [synthesis]
Carry out all catalytic reactions in reaction vessels open to the air.
Charge a round-bottom flask with the newly purchased or freshly
recrystallized aryl boronic acid (2.0 mmol), 1,2-dibromobenzene,
powdered K3PO4 (2.2 mmol) and toluene (2.5 mL) of
technical quality. Stir the mixture vigorously. Heat the mixture to 80
°C for 10 minutes. Add (0.2 mol%) of catalyst by syringe as a 2.5 ml of
toluene solution to the mixture. Take the samples periodically from the
reaction mixture. Quench the reaction with water. Extract the mixture
with ethyl acetate. Analyze the reaction by GC-MS. At the end of
catalytic reaction, cool the reaction mixture to room temperature.
Quench the mixture with water (adjusted to an appropriate pH when
biaryls with acidic or basic groups has to be extracted). Extract the
mixture with ethyl acetate (3×40 mL). Dry the combined extracts (MgSO4). Evaporate the combined extracts to dryness. Purify the crude material by flash chromatography on silica gel. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29036990 |
| Hazard Information | Back Directory | [General Description]
Clear liquid. Insoluble in water. | [Reactivity Profile]
2-BROMOBIPHENYL(2052-07-5) is sensitive to light. Low reactivity. | [Air & Water Reactions]
Insoluble in water. | [Fire Hazard]
Flash point data for this chemical are not available. 2-BROMOBIPHENYL is probably combustible. | [Chemical Properties]
Liquid | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 44, p. 3037, 1979 DOI: 10.1021/jo01331a016
Tetrahedron Letters, 21, p. 845, 1980 DOI: 10.1016/S0040-4039(00)71521-8 |
|
|