| Identification | Back Directory | [Name]
Z-PHE-DL-ALA-FLUOROMETHYLKETONE | [CAS]
197855-65-5 | [Synonyms]
CS-1504
Z-PHE-DL-ALA-FLUOROMETHYLKETONE
Nalpha-[(Benzyloxy)Carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide
Nalpha-[(Benzyloxy)Carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide z-fa-fmk
Carbamic acid,N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-,phenylmethyl ester | [Molecular Formula]
C21H23FN2O4 | [MDL Number]
MFCD02684535 | [MOL File]
197855-65-5.mol | [Molecular Weight]
386.42 |
| Chemical Properties | Back Directory | [Boiling point ]
630.5±55.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMF: 5 mg/ml; DMSO: 5 mg/ml | [form ]
White solid | [pka]
11.07±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Z-FA-FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain.1 It also inhibits effector caspases-2, -3, -6, and -7 (IC50 = 6-32 μM) without affecting the initiator caspases-8 and -10.2 Z-FA-FMK also modulates infection by certain bacteria, parasites, and viruses.3,4,5 It can be used both in cells and in vivo.4,5 | [Uses]
Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain. |
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