| Identification | More | [Name]
PELITINIB | [CAS]
257933-82-7 | [Synonyms]
PELITINIB
WAY-EKB 569
Pelitinib(EKB-569)
EKB-569 Pelitinib
N-[4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)-2(E)-but·Namide
(E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide
(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
(2E)-N-{4-[(3-chloro-4-fluorophenyl)aMino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(diMethylaMino)but-2-enaMide
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
Pelitinib (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
(2e)-n-(4-((3-chloro-4-fluorophenyl)aMino)-3-cyano-7-ethoxy-6-quinolinyl)-4-(diMethylaMino)-2-butenaMide pelitinib | [EINECS(EC#)]
803-625-4 | [Molecular Formula]
C24H23ClFN5O2 | [MDL Number]
MFCD09837868 | [MOL File]
257933-82-7.mol | [Molecular Weight]
467.93 |
| Chemical Properties | Back Directory | [Melting point ]
173-178°C | [Boiling point ]
655.5±55.0 °C(Predicted) | [density ]
1.34 | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO: soluble5mg/mL, clear (warmed) | [form ]
powder | [pka]
12.23±0.43(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Usage]
An EGFR inhibitor | [Usage]
Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer. | [Usage]
Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. | [Description]
Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM).1 It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM).1 By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).2 | [Uses]
An EGFR inhibitor | [Uses]
Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer. | [Uses]
Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. | [Definition]
ChEBI: Pelitinib is an aminoquinoline, a nitrile, a monocarboxylic acid amide and a member of monochlorobenzenes. It has a role as a protein kinase inhibitor. | [target]
EGFR | [storage]
Store at -20°C | [References]
[1] torrance cj, jackson pe, montgomery e, kinzler kw, vogelstein b, wissner a, nunes m, frost p, discafani cm. combinatorial chemoprevention of intestinal neoplasia. nat med. 2000 sep;6(9):1024-8.
[2] nunes m, shi c, greenberger lm. phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase b, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, ekb-569, in tumor cells and normal human keratinocytes. mol cancer ther. 2004 jan;3(1):21-7. |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [HS Code ]
2933.59.8000 | [HazardClass ]
6.1 | [PackingGroup ]
III |
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