| Identification | Back Directory | [Name]
E-64C | [CAS]
76684-89-4 | [Synonyms]
E-64C
NSC 694279
E-64c, EP 475
Loxistatin acid
anecarboxylicacid
ep475(enzymeinhibitor)
Loxistatin Acid (E-64C)
Inhibitorforthiolprotease
NSC 694279 Loxistatin Acid
E-64-c Loxistatin acid NSC 694279
(2s-(2-alpha,3-beta(r*)))-mino)carbonyl)
L-TRANS-EPOXYSUCCINYL-LEU-3-METHYLBUTYLAMIDE
NSC 694279 LOXISTATIN ACID; EP 475;E64C;E 64C
(2S,3S)-TRANS-EPOXYSUCCINYL-L-*LEUCYLAMI DO-3-METHYL
(2S,3S)-TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-3-METHYLBUTANE
(2S,3S)-L-TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-3-METHYLBUTANE
(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCINE (3-METHYLBUTYL)AMIDE
(+)-(2s,3s)-3-((s)-3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxir
oxiranecarboxylicacid,3-(((3-methyl-1-(((3-methylbutyl)amino)carbonyl)butyl)a
(1S,2S)-2-(((S)-1-(Isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)cyclopropanecarboxylic
(2S,3S)-3-[[(1S)-1-(3-Methylbutylcarbamoyl)-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid
(2S,3S)-3-(((S)-1-(isopentylaMino)-4-Methyl-1-oxopentan-2-yl)carbaMoyl)oxirane-2-carboxylic acid
(2S)-3β-[[[(S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2α-oxiranecarboxylic acid
2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,(2S,3S)- | [Molecular Formula]
C15H26N2O5 | [MDL Number]
MFCD00132882 | [MOL File]
76684-89-4.mol | [Molecular Weight]
314.38 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
≥31.4 mg/mL in DMSO; insoluble in H2O; ≥111.8 mg/mL in EtOH | [form ]
White to off-white solid | [color ]
White to off-white | [biological source]
synthetic (organic) | [InChIKey]
SCMSYZJDIQPSDI-SRVKXCTJSA-N |
| Hazard Information | Back Directory | [Description]
E-64c is an active metabolite of the protease inhibitor E-64d (Item No. 13533).1,2,3,4 E-64c inhibits the cysteine proteases cathepsin B, cathepsin H, and papain but not the serine proteases trypsin, chymotrypsin, or elastase.5,6 It reduces the autocatalytic activity of the foot-and-mouth-disease virus (FMDV) leader protease when used at concentrations ranging from 0.1 to 1 mg/ml.3 E-64c reduces infection of HEK293T cells by an HIV-based virus system pseudotyped with severe acute respiratory syndrome coronavirus (SARS-CoV) surface glycoprotein, also known as the spike glycoprotein, in a concentration-dependent manner.4 | [Uses]
Cell-impermeable epoxysuccinyl peptide inhibitor of calpain and other cysteine proteases. Inhibits calpain and cathepsins B, H, and L. | [Definition]
ChEBI: E-64c is a leucine derivative. | [target]
cathepsins B |
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| Company Name: |
DKMbiochem.Co. Ltd Gold
|
| Tel: |
15901859516 |
| Website: |
http://www.dkmbiochem.com/ |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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