| Identification | More | [Name]
1-N-Boc-3-hydroxyazetidine | [CAS]
141699-55-0 | [Synonyms]
1-BOC-3-(HYDROXY)AZETIDINE
1-N-BOC-3-HYDROXYAZETIDINE
3-HYDROXY-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
3-HYDROXYAZETIDINE, N-BOC PROTECTED
BUTTPARK 75\04-65
N-BOC-3-HYDROXYAZETIDINE
TERT-BUTYL 3-HYDROXYAZETIDINE-1-CARBOXYLATE
1-TERT-BUTOXYCARBONYL-3-AZETIDINOL
1-TERT-BUTOXYCARBONYL-3-HYDROXYAZETIDINE
3-Hydroxyazetidine, N-BOC protected 97%
1-tert-Butoxycarbonyl-3-azetidinol
tert-butyl 3-hydroxyazetidine-1-carboxylate
1-BOC-3-(HYDROXY)AZETIDINE
1-(tert-Butoxycarbonyl)-3-azetidinol
1-(TERT-BUTOXYCARBONYL)-3-HYDROXYAZETIDINE,98.0%(GC)
1-Boc-azetidin-3-ol
1-Azetidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester | [EINECS(EC#)]
628-534-5 | [Molecular Formula]
C8H15NO3 | [MDL Number]
MFCD04115305 | [Molecular Weight]
173.21 | [MOL File]
141699-55-0.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
36-43 °C | [Boiling point ]
253.7±33.0 °C(Predicted) | [density ]
1.184±0.06 g/cm3(Predicted) | [Fp ]
>110℃ | [storage temp. ]
2-8°C | [solubility ]
soluble in Methanol | [form ]
Solid | [pka]
14.16±0.20(Predicted) | [color ]
White to light yellow | [InChIKey]
XRRXRQJQQKMFBC-UHFFFAOYSA-N | [CAS DataBase Reference]
141699-55-0(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R41:Risk of serious damage to eyes.
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [TSCA ]
No | [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs | [IC 50]
Non-cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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