| Identification | More | [Name]
1-Methyl-3-pyrrolidinol | [CAS]
13220-33-2 | [Synonyms]
1-METHYL-3-PYRROLIDINOL
1-METHYL-PYRROLIDIN-3-OL
3-HYDROXY-1-METHYLPYRROLIDINE
3-HYDROXY-N-METHYLPYRROLIDINE
N-METHYL-3-HYDROXY PYRROLIDINE
3-Pyrrolidinol, 1-methyl-
N-Methyl-3-pyrrolidinol
N-Methyl-pyrrolidin-3-ol
1-Methyl-3-hydroxypyrrolidine
NSC 89279
N-Methyl-pyrrolidinyl alcohol | [EINECS(EC#)]
236-189-3 | [Molecular Formula]
C5H11NO | [MDL Number]
MFCD00003176 | [Molecular Weight]
101.15 | [MOL File]
13220-33-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless to pale yellow liquid | [Boiling point ]
50-52 °C1 mm Hg(lit.)
| [density ]
0.921 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.464(lit.)
| [Fp ]
159 °F
| [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Oil | [pka]
14.95±0.20(Predicted) | [color ]
Colourless | [InChI]
InChI=1S/C5H11NO/c1-6-3-2-5(7)4-6/h5,7H,2-4H2,1H3 | [InChIKey]
FLVFPAIGVBQGET-UHFFFAOYSA-N | [SMILES]
N1(C)CCC(O)C1 | [CAS DataBase Reference]
13220-33-2(CAS DataBase Reference) | [NIST Chemistry Reference]
1-Methyl-3-pyrrolidinol(13220-33-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to pale yellow liquid | [Uses]
1-Methyl-3-pyrrolidinol (cas# 13220-33-2) is a compound useful in organic synthesis. | [Synthesis]
A 500 mL four-necked flask was charged with a 40 wt% aqueous solution of monomethylamine and cooled to 10 ° C in an ice-water bath. Then, while stirring, 1,4-dichloro-2-butanol was added dropwise, and the temperature was controlled at 15 ° C. Then pour the system into an Autoclave, sealed, evacuated to a pressure of 1.0 ± 0.1MPa, while heated to 120 ℃, the reaction was stirred for about 10h. After the reaction was over and cooled to room temperature, the material was discharged, batch-wise added sodium hydroxide was released, and a large amount of methylamine gas, controlling the temperature below 50 ℃, precipitated a lot of white solid, stirred for 1h; filtration, the filtrate layered, the upper organic phase Ethanol And anhydrous magnesium sulfate, stirring 2 ~ 3h; and then filtered, the filtrate was concentrated in vacuo to give a yellow transparent oily liquid, and then vacuum distillation to give colorless and t1-Methyl-3-pyrrolidinol, Yield 64.8%, purity 99.3%.
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