| Identification | More | [Name]
Propylene carbonate | [CAS]
108-32-7 | [Synonyms]
1,2-PROPANEDIOL CYCLIC CARBONATE
1,2-PROPYLENE CARBONATE
1,2-PROPYLENE GLYCOL CARBONATE
2-OXO-4-METHYL-1,3-DIOXOLANE
4-METHYL-1,3-DIOXOL-2-ONE
4-METHYL-1,3-DIOXOLAN-2-ONE
4-METHYL-1,3-DIOXOLANE-2-ONE
ARCONATE
ARCONATE(R) PC
CARBONIC ACID CYCLIC PROPYLENE ESTER
CARBONIC ACID PROPYLENE GLYCOL ESTER
PC
PROPANEDIOL CYCLIC CARBONATE
PROPYLENE CARBONATE
PROPYLENE CARBONATE S
PROPYLENE GLYCOL CARBONATE
(±)-Methyl-1,3-dioxolan-2-one
(R,S)-4-Methyl-[1,3]dioxolan-2-one
1,2-PDC
1,2-Propanediol carbonate | [EINECS(EC#)]
203-572-1 | [Molecular Formula]
C4H6O3 | [MDL Number]
MFCD00005385 | [Molecular Weight]
102.09 | [MOL File]
108-32-7.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless liquid | [Melting point ]
-55 °C (lit.) | [Boiling point ]
240 °C (lit.) | [density ]
1.204 | [vapor pressure ]
0.13 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.421(lit.)
| [Fp ]
270 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
240g/l | [form ]
Liquid | [pka]
3.92[at 20 ℃] | [color ]
Clear | [Specific Gravity]
1.209 (20/4℃) | [Odor]
odorless | [PH]
7.0 (200g/l, H2O, 20℃) | [Relative polarity]
6 | [Stability:]
Stable. Incompatible with strong oxidizing agents, acids, bases, reducing agents. Protect from contact with moist air or water. | [explosive limit]
1.8-14.3%(V) | [Water Solubility ]
240 g/L (20 ºC) | [λmax]
λ: 235 nm Amax: 1.00
λ: 280 nm Amax: 0.50
λ: 300 nm Amax: 0.30
λ: 350 nm Amax: 0.05
λ: 375-400 nm Amax: 0.01 | [BRN ]
107913 | [Dielectric constant]
64.4（Ambient） | [InChIKey]
RUOJZAUFBMNUDX-UHFFFAOYSA-N | [LogP]
-0.41 at 20℃ | [Uses]
propylene carbonate is used in chemical reactions as a solvent, plasticizer, solubilizer, or dilutent. | [CAS DataBase Reference]
108-32-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Propylene carbonate(108-32-7) | [EPA Substance Registry System]
Propylene carbonate (108-32-7) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
1
| [RTECS ]
FF9650000
| [F ]
3-10 | [Autoignition Temperature]
851 °F | [TSCA ]
Yes | [HS Code ]
29209010 | [Hazardous Substances Data]
108-32-7(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 20000 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
colourless liquid | [Chemical Properties]
Propylene carbonate is a clear, colorless, mobile liquid, with a faint
odor. | [Preparation]
To a stirred solution of 1,2- propanediol 957 (230 mg, 3.0 mmol) in toluene (8 mL) was added DPC (670 mg, 3.1 mmol). After stirring at 110 ℃ for 1.5 h, the reaction mixture was allowed to cool to room temperature, diluted with dichloromethane (40 mL), washed with brine (30 mL), dried over anhydrous MgSO4, and concentrated to dryness under reduced pressure. The crude product was distilled in vacuo in a kugelrohr apparatus to give 4-methyl-1,3-dioxolan-2-one 958 (254 mg) in 83% yield. | [Production Methods]
Propylene carbonate may be prepared by the reaction of sodium
bicarbonate with propylene chlorohydrin. | [General Description]
Propylene carbonate is a cyclic carbonate commonly used as an organic solvent. Many methods have been reported for its synthesis from propylene oxide and carbon dioxide under different reaction conditions. The dielectric property, relaxation times and viscosity has been studied. It is a potential electrochemical solvent in preparing aprotic battery electrolytes. | [Flammability and Explosibility]
Notclassified | [Pharmaceutical Applications]
Propylene carbonate is used mainly as a solvent in oral and topical
pharmaceutical formulations.
In topical applications, propylene carbonate has been used in
combination with propylene glycol as a solvent for corticosteroids.
The corticosteroid is dissolved in the solvent mixture to yield microdroplets that can then be dispersed in petrolatum.Propylene
carbonate has been used as a dispensing solvent in topical
preparations.
Propylene carbonate has also been used in hard gelatin capsules
as a nonvolatile, stabilizing, liquid carrier. For formulations with a
low dosage of active drug, a uniform drug content may be obtained
by dissolving the drug in propylene carbonate and then spraying
this solution on to a solid carrier such as compressible sugar; the
sugar may then be filled into hard gelatin capsules
Propylene carbonate may additionally be used as a solvent, at
room and elevated temperatures, for many cellulose-based polymers
and plasticizers. Propylene carbonate is also used in cosmetics. | [Safety]
Propylene carbonate is used as a solvent in oral and topical
pharmaceutical formulations, and is generally regarded as an
essentially nontoxic and nonirritant material.
In animal studies, propylene carbonate was found to cause tissue
necrosis after parenteral administration.
(mouse, oral): 20.7 g/kg
(mouse, SC): 15.8 g/kg
(rat, oral): 29 g/kg
(rat, SC): 11.1 g/kg | [storage]
Propylene carbonate and its aqueous solutions are stable but may
degrade in the presence of acids or bases, or upon heating;
Store in a well-closed container in a cool, dry place. | [Purification Methods]
It is manufactured by reaction of 1,2-propylene oxide with CO2 in the presence of a catalyst (quaternary ammonium halide). Contaminants include propylene oxide, carbon dioxide, 1,2-and 1,3-propanediols, allyl alcohol and ethylene carbonate. It can be purified by percolation through molecular sieves (Linde 5A, dried at 350o for 14hours under a stream of argon), followed by distillation under a vacuum. [Jasinski & Kirkland Anal Chem 39 163 1967.] It can be stored over molecular sieves under an inert gas atmosphere. When purified in this way it contains less than 2ppm of water. Activated alumina and dried CaO have also been used as drying agents prior to fractional distillation under reduced pressure. It has been dried with 3A molecular sieves and distilled under nitrogen in the presence of p-toluenesulfonic acid, then redistilled and the middle fraction collected. [Beilstein 19 III/IV 1564, 19/4 V 21.] | [Incompatibilities]
Propylene carbonate hydrolyzes rapidly in the presence of strong
acids and bases, forming mainly propylene oxide and carbon
dioxide. Propylene carbonate can also react with primary and
secondary amines to yield carbamates. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (topical
ointments). Included in the Canadian List of Acceptable Nonmedicinal
Ingredients. |
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