ChemicalBook CAS DataBase List Tos-PEG3-CH2CO2tBu

Tos-PEG3-CH2CO2tBu synthesis

4synthesis methods

Product Name:Tos-PEG3-CH2CO2tBu
CAS Number:882518-89-0
Molecular formula:C17H26O7S
Molecular Weight:374.45

149299-82-1
78 suppliers
$37.00/100mg

98-59-9 Synthesis

98-59-9
588 suppliers
$9.00/5g

882518-89-0
44 suppliers
$69.00/100mg

Yield: 84%

Reaction Conditions:

with triethylamine in dichloromethane at 0 - 20; for 3 h;

Steps:

1 Example Synthesis of Exemplary Compound 11 Step 1
To a mixture of tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)acetate (1.5 g, 6.8 mmol) and TEA (2.07 g, 20.5 mmol) in DCM (5 mL) was added TsCl (1.95 g, 10.23 mmol) at 0° C. The resulting mixture was warmed to room temperature and stirred for 3 hours. The solution was quenched with water (20 mL), and extracted with DCM. The organic phase was washed with brine (20 mL×2). The organic phase was dried over Na₂SO₄, filtered and concentrated. The residue was purified by flash chromatography (CH₂Cl₂:MeOH 40:1) to give tert-butyl 2-(2-(2-(tosyloxy)ethoxy)ethoxy)acetate (2.14 g, mmol, 84% yield).

References:

Arvinas Operations, Inc.;Genentech, Inc.;Crew, Andrew P.;Wang, Jing;Berlin, Michael;Dragovich, Peter;Chen, Huifen;Staben, Leanna US2019/300521, 2019, A1 Location in patent:Paragraph 0620-0621

5292-43-3 Synthesis