tert-Butyl bromoacetate synthesis
- Product Name:tert-Butyl bromoacetate
- CAS Number:5292-43-3
- Molecular formula:C6H11BrO2
- Molecular Weight:195.05
Yield:5292-43-3 97.6%
Reaction Conditions:
with perfluorosulfonic acid resin in tetrahydrofuran at 10 - 15; for 5 h;Large scale;Green chemistry;Concentration;Temperature;
Steps:
2 Example 2 A green synthesis method of tert - butyl bromoacetate
To the reaction vessel was added 139 kg (1.0 mol) of bromoacetic acid, 400 L of tetrahydrofuran, 17.5 kg of perfluorosulfonic acid resin,Mixing, heating to 10 ° C to 15 ° C, slowly passing 78.5 kg (1.4 mol) of isobutylene gas, holding the reaction for 5 hours, sampling and samplingTLC (developing agent for ethyl acetate: petroleum ether = 3: 1) detection, to bromoacetic acid reaction completely. Filtration, recovery of perfluorosulfonic acid resin reminderThe filtrate was distilled under reduced pressure to recover the solvent and then distilled to collect a positive boiling temperature of 160 ° C to 165 ° C to obtain 190.3 kg of bromineAcid tert-butyl ester, the product purity of 99.6%, the yield of 97.6% (in bromoacetic acid).
References:
CN106380398,2017,A Location in patent:Paragraph 0011; 0012
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5292-43-3
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75-65-0
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$10.00/10ml
5292-43-3
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$10.00/5g
