tert-Butyl 2-bromo-2-methylpropanoate synthesis
- Product Name:tert-Butyl 2-bromo-2-methylpropanoate
- CAS Number:23877-12-5
- Molecular formula:C8H15BrO2
- Molecular Weight:223.11
2052-01-9
274 suppliers
$10.00/1g
75-65-0
770 suppliers
$10.00/10ml
23877-12-5
346 suppliers
$7.00/5g
Yield:23877-12-5 125 g
Reaction Conditions:
with 4-methoxy-phenol;isobutene in dichloromethane at 41; for 5 h;Reflux;Reagent/catalyst;Temperature;
Steps:
5 Example 5
Into a three-necked flask having a capacity of 500 mL, 100 g of? -bromoisobutyric acid, 200 g of dichloromethane,1 g of p-hydroxyanisole,10 g of t-butanol, and then 5 g of CH-A type and 5 g of CHR-06 type cation exchange resin, respectively,The control temperature was 41 ° C,And do return. After the start of the reflux, 55 g of isobutene was fed to the reaction over 2 h,After 3h, the reaction solution was obtained. After the reaction, the cation exchange resin was filtered off,The reaction solution was adjusted to pH 6.5 with triethylamine and then subjected to atmospheric distillation at 80 ° C,And distilled under reduced pressure to obtain 125 g of t-butyl? -bromoisobutyrate in a purity of 99%.
References:
CN105601510,2016,A Location in patent:Paragraph 0032; 0033; 0034
20769-85-1
266 suppliers
$13.00/5g
75-65-0
770 suppliers
$10.00/10ml
23877-12-5
346 suppliers
$7.00/5g
2052-01-9
274 suppliers
$10.00/1g
1493-13-6
654 suppliers
$12.00/5g
23877-12-5
346 suppliers
$7.00/5g
115-11-7
242 suppliers
$45.00/25g
23877-12-5
346 suppliers
$7.00/5g