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ChemicalBook CAS DataBase List (S)-1-(2-Aminoacetyl)-pyrrolidine-2-carbonitrile
914070-99-8

(S)-1-(2-Aminoacetyl)-pyrrolidine-2-carbonitrile synthesis

6synthesis methods
214398-99-9 Synthesis
(S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxaMide

214398-99-9
162 suppliers
$90.00/50mg

(S)-1-(2-Aminoacetyl)-pyrrolidine-2-carbonitrile

914070-99-8
20 suppliers
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Yield:-

Reaction Conditions:

Stage #1: (S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamidewith trifluoroacetic anhydride in tetrahydrofuran at 0 - 20; for 6 h;
Stage #2: with ammonium hydroxide at -20 - 20; for 3 h;

References:

Lizza, Joseph R.;Patel, Savan V.;Yang, Catherine F.;Moura-Letts, Gustavo [European Journal of Organic Chemistry,2016,vol. 2016,# 30,p. 5160 - 5168] Location in patent:supporting information

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