L-Prolinamide synthesis
- Product Name:L-Prolinamide
- CAS Number:7531-52-4
- Molecular formula:C5H10N2O
- Molecular Weight:114.15
16395-58-7
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Yield:7531-52-4 95.3%
Reaction Conditions:
with hydrogenchloride in water at 103; for 2 h;Temperature;
Steps:
1; 2; 3; 4
44.41 g of 1-acetyl-2-pyrrolidinecarboxamide was added to 160 mL of 2N HCl.Raise the temperature to 103 ° C reflux reaction,During the reaction, the temperature of the system is kept at the micro-reflow state.Co-reacted for 2 hours,After completion of the reaction, the mixture was concentrated to a small volume until crystallization, pH was adjusted to 8, filtered, and dried to give the desired product, L-prolinamide, 31.05 g, yield 95.3%. Detection of D-type isomerismThe purity of the solution was 0.11%, and the purity was determined by high performance liquid chromatography HPLC to be 99.1%.
References:
CN109111386,2019,A Location in patent:Paragraph 0030; 0034; 0035; 0039; 0040; 0044; 0045; 0049
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34079-31-7
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![2-Pyrrolidinecarboxamide, 1-[(1S)-1-phenylethyl]-, (2S)-](/CAS/20200611/GIF/929897-95-0.gif)
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