ChemicalBook CAS DataBase List QUINOLINE-4-CARBOXYLIC ACID

QUINOLINE-4-CARBOXYLIC ACID synthesis

15synthesis methods

Product Name:QUINOLINE-4-CARBOXYLIC ACID
CAS Number:486-74-8
Molecular formula:C10H7NO2
Molecular Weight:173.17

91-56-5 Synthesis

91-56-5
454 suppliers
$5.00/25g

67-64-1
6 suppliers
$17.30/10ml

486-74-8
245 suppliers
$15.00/250mg

Yield:486-74-8 52%

Reaction Conditions:

with water;potassium hydroxideReflux;

Steps:

2.213.1 Step 1
Add indoline-2,3-dione (1g, 6.87mmol) to a 100ml round bottom flask, add an aqueous solution (7.2ml) of KOH (3.6g, 54.4mmol), stir for 5 minutes and add 12ml Acetone was heated to reflux overnight. After the reaction was completed, the pH was adjusted to between 5 and 6 with 1N HCl. A solid precipitated, and the product was filtered to obtain 666 mg, with a yield of 52%.

References:

Chinese Academy Of Sciences Shanghai Pharmaceutical Institute;Chen Xiaohua;Li Jia;Cheng Yu;Zhou Yubo;Nie Huijun;Wang Yujie;Tian Hongtao;Kan Weijuan;Mi Tian;Hu Xiaobei;Zhou Binshan;Yan Kenian;Xu Gaoya;Zhong Yuhua;Feng Lei CN110963994, 2020, A Location in patent:Paragraph 0475; 1159-1161

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