2-CHLOROQUINOLINE-4-CARBOXYLIC ACID synthesis
- Product Name:2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
- CAS Number:5467-57-2
- Molecular formula:C10H6ClNO2
- Molecular Weight:207.61
15733-89-8
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5467-57-2
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Yield: 87.5%
Reaction Conditions:
with trichlorophosphate for 1 h;Reflux;
Steps:
16.b
b) The product of the previous step (10.2 g, 53.9 mmol) was dissolved in 20 mL of phosphorus oxychloride and refluxed for 1 h. The phosphorus oxychloride was removed by rotary evaporation, the residue was poured into ice water, the pH was adjusted to 4-5 with a saturated aqueous solution of sodium bicarbonate, suction filtered, washed with water and dried to obtain 9.8 g of 2-chloroquinoline-4-carboxylic acid, the yield was 87.5%;
References:
China Pharmaceutical University;Xu Jinyi;Li Wenlong;Xu Shengtao;Xu Feijie;Shuai Wen;Sun Honghao;Zhu Zheying;Yao Hong CN109467549, 2019, A Location in patent:Paragraph 0027; 0100; 0104
15733-89-8
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$14.14/1gm:
5467-57-2
146 suppliers
$6.00/250mg
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5467-57-2
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5467-57-2
146 suppliers
$6.00/250mg