N-Ethyl-4-methoxybenzylamine synthesis
- Product Name:N-Ethyl-4-methoxybenzylamine
- CAS Number:22993-76-6
- Molecular formula:C10H15NO
- Molecular Weight:165.23
7403-41-0
13 suppliers
$57.00/250mg
22993-76-6
83 suppliers
$24.00/1g
105-13-5
561 suppliers
$5.00/5G
Yield:22993-76-6 92 %Spectr. ，105-13-5 7 %Spectr.
Reaction Conditions:
with 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane in neat (no solvent) at 120; for 24 h;Inert atmosphere;Sealed tube;
Steps:
General procedure for hydroboration of secondary and tertiary amides
General procedure: N,N-dimethylbenzamide (0.0746 g,0.5 mmol), or N-methylbenzamide (0.0676 g, 0.5 mmol) was taken in culture tube (11 ml) at 25 °C, sealed with septum, the air in culture tube was replaced with argon gas. After adding pinacolborane (0.36 ml, 2.5 mmol 5 equiv), the screw cap was closed, stirred at 120 °C for 24 h. Afterthis time, it was cooled to room temperature, excess HBpin was quenched by adding water (0.1 ml). After adding 2 ml of 5 N NaOH (aq), reaction mixture was extracted with ether (20 ml). The organic part was dried over MgSO4, filtered and dried under high vacuum to remove volatile organic impurities. The yield was analyzed by 1HNMR (using acetonitrile [8μl, 0.33 eq] as an internal standard).
References:
Yi, Jaeeun;Kim, Hyun Tae;Jaladi, Ashok Kumar;An, Duk Keun [Bulletin of the Korean Chemical Society,2022,vol. 43,# 1,p. 129 - 132]
2393-23-9
469 suppliers
$20.00/25g
75-05-8
991 suppliers
$10.00/10g
22993-76-6
83 suppliers
$24.00/1g
7403-41-0
13 suppliers
$57.00/250mg
22993-76-6
83 suppliers
$24.00/1g
2393-23-9
469 suppliers
$20.00/25g
22993-76-6
83 suppliers
$24.00/1g