ChemicalBook CAS DataBase List 4-Methoxybenzylamine

4-Methoxybenzylamine synthesis

11synthesis methods

Product Name:4-Methoxybenzylamine
CAS Number:2393-23-9
Molecular formula:C8H11NO
Molecular Weight:137.18

123-11-5 Synthesis

123-11-5
863 suppliers
$10.00/10g

2393-23-9
465 suppliers
$20.00/25g

Yield:2393-23-9 95.78%

Reaction Conditions:

with aluminum-nickel-iron ternary catalyst;ammonia;hydrogen in methanol at 25 - 85; under 7500.75 - 11251.1 Torr; for 12 h;Sealed tube;Reagent/catalyst;

Steps:

1-5 Example 2:

Drop into methanol 900g in the hydrogenation kettle, add p-methoxybenzaldehyde 300g,Then add 30g of aluminum-nickel-iron ternary catalyst, seal the hydrogenation kettle, and replace the system with nitrogen.At 25-35°C, add 150g of liquid ammonia under stirring, keep the hydrogen pressure at 1.0-1.5MPa,The system temperature was at 75-85°C, and the reaction was stirred for 12 hours. cooling, depressurization,The catalyst was removed by filtration, the filtrate was concentrated, distilled and rectified under stirring,322.5 g of p-methoxybenzylamine were obtained with a yield of 95.78%. The titrated content is 99.8%.

References:

CN113683520,2021,A Location in patent:Paragraph 0025-0029