6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride synthesis
- Product Name:6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
- CAS Number:2328-12-3
- Molecular formula:C11H16ClNO2
- Molecular Weight:229.7
Yield:2328-12-3 61.8%
Reaction Conditions:
Stage #1:formaldehyd;2-(3,4-dimethoxyphenyl)-ethylamine in ethanol at 20; for 3 h;
Stage #2: with hydrogenchloride in ethanol;water; pH=2 for 4 h;Reflux;
Steps:
1 Example 1Preparation of 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (ii)
In a 250 ml single-necked flask, 3,4-dimethoxyphenylethylamine (18.1 g, 100 mmol) and paraformaldehyde (3.6 g,120mmol), absolute ethanol (30ml). After stirring for 3 h at room temperature, the pH was adjusted to 2 with concentrated hydrochloric acid, and the mixture was heated to reflux for 4 h. The mixture was cooled and filtered.White crystalline hydrochloride salt 14.2 g, yield 61.8%
References:
China Pharmaceutical University;Huang Wenlong;Qian Hai;Liao Chen;He Siman;Li Huilan CN107573325, 2018, A Location in patent:Paragraph 0109; 0110; 0111
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