N-BOC-3-Aminopiperidine synthesis
- Product Name:N-BOC-3-Aminopiperidine
- CAS Number:184637-48-7
- Molecular formula:C10H20N2O2
- Molecular Weight:200.28
478828-62-5
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$166.09/250mg
184637-48-7
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$6.00/1g
Yield:184637-48-7 97%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 45; for 3 h;Cooling with ice;
Steps:
5 5. Preparation of (R) -piperidine-3-ylcarbamic acid tert-butyl ester:
In an ice bath, 247 g of (R)-(1-benzylpiperidin-3-yl) carbamic acid tert-butyl ester (851 mmmol), 2470 g of methanol and 5 g of palladium carbon (10 w%) were added to a three-necked reaction flask;Hydrogen was replaced 3 times, and then the system was raised to 45 ° C for 3h; the reaction was monitored by TLC.The system was cooled to room temperature, filtered, and the filtrate was concentrated to dryness to obtain 165 g of tert-butyl (R) -piperidin-3-ylcarbamate (purity 95%; yield 97%).
References:
Suzhou Hande Chuanghong Biochemical Technology Co., Ltd.;Mao Zhongping;Ma Dongxu;Wei Hua CN110372573, 2019, A Location in patent:Paragraph 0068-0071
406213-47-6
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56700-70-0
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635722-83-7
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184637-48-7
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24424-99-5
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184637-48-7
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