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ChemicalBook CAS DataBase List METOLCARB
1129-41-5

METOLCARB synthesis

3synthesis methods
Metolcarb is produced by the reaction between 3- methylphenol and Metolcarb.
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Yield:1129-41-5 78%

Reaction Conditions:

with methylamine in toluene

Steps:

4 PREPARATION OF 3-METHYLPHENYL METHYLCARBAMATE
EXAMPLE 4 PREPARATION OF 3-METHYLPHENYL METHYLCARBAMATE A solution of 3-methylphenol (64.9 g, 0.600 mole) in 500 g of toluene was heated under nitrogen to 95° C. Phosgene (76.0 g, 0.77 mole) and methylamine (16.0 g, 0.52 mole) were metered into the stirred solution as gases concurrently and gradually over a period of 4.5 hours, while the temperature was maintained at 96°-98° C. After an additional half hour at the same temperature, the hot mixture was filtered; the filtrate was concentrated to yield 103.5 g of an oil which contained 3-methylphenyl methylcarbamate in a 78% yield.

References:

FMC Corporation US4272441, 1981, A

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