ChemicalBook CAS DataBase List Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate

Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate synthesis

6synthesis methods

Product Name:Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate
CAS Number:205448-66-4
Molecular formula:C12H10ClNO3
Molecular Weight:251.67

205448-65-3 Synthesis

Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate

205448-65-3
166 suppliers
$13.00/100mg

Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate

205448-66-4
219 suppliers
$9.00/250mg

Yield:205448-66-4 94.53%

Reaction Conditions:

with trichlorophosphate in toluene at 25 - 95;

Steps:

1 Example 1: Preparation of Methyl 4-chloro-7-methoxyguinoline-6-carboxylate.
10.0 g of methyl 7-methoxy-4-oxo-1, 4-dthydroquinoline-6-carboxylate, 90 mL of toluene and 8.2 g of phosphoryl chloride were taken in a flask at 25-3OoC and heated to 90-95oC for 3-4 hours. The reaction was cooled to 25-3OoC and 100 mL of demineralized water was added to the above reaction mass. The organic layer was washed with 50 mL of demineralized water and to this 41 mL of 20% sodium hydroxide solution was added. The resulting compound was filtered, washed and dried under reduced pressure to obtain the title compound.Yield: 94.53 %; HPLC purity: 99.61%

References:

DR. REDDY'S LABORATORIES LIMITED;ARKALA, Anil Kumar Reddy;BHALERAO, Dinesh;MAHAPATRA, Tridib;MOVVA, Venkateswarlu;JINNA, Rajendar Reddy;ELATI, Raviram Chandrasekhar WO2019/92625, 2019, A1 Location in patent:Page/Page column 8; 9

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205448-65-3 Synthesis

205448-65-3
166 suppliers
$13.00/100mg

75-09-2 Synthesis