ChemicalBook CAS DataBase List Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate

Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate synthesis

4synthesis methods

Product Name:Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
CAS Number:205448-65-3
Molecular formula:C12H11NO4
Molecular Weight:233.22

205448-64-2 Synthesis

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester

205448-64-2
79 suppliers
$25.00/250mg

Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate

205448-65-3
158 suppliers
$13.00/100mg

Yield:205448-65-3 80.7%

Reaction Conditions:

in diphenylether;biphenyl at 170 - 185; for 0.75 h;Inert atmosphere;

Steps:

3
45 g (292 mmol) of biphenyl was weighed into a three-necked flask, 150 mL of diphenyl ether was added, the solvent was heated to 180 ° C under nitrogen atmosphere, and 18 g (53.7 mmol) of compound 4 was rapidly added under a nitrogen atmosphere, and a large amount of gas was released. The temperature was maintained at 170 to 185 ° C, and the reaction was continued for 45 minutes to stop the heating. Cooled to room temperature, a large amount of yellow solid precipitated, added petroleum ether, filtered, filter cakeThe crude product was washed well with diethyl ether.The crude product was purified by petrol-ethyl acetate (5:2 by volume), suction filtered and dried.A yellow solid (5) of 10.11 g was obtained in a yield of 80.7%.

References:

Nanjing Tian Yue Xing Biological Co., Ltd.;Wu Xueping;Chen Yao CN109456267, 2019, A Location in patent:Paragraph 0026; 0027

27492-84-8 Synthesis