CYCLOPROPANECARBOXAMIDE synthesis

8synthesis methods

Product Name:CYCLOPROPANECARBOXAMIDE
CAS Number:6228-73-5
Molecular formula:C4H7NO
Molecular Weight:85.1

4023-34-1 Synthesis

4023-34-1
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6228-73-5
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$5.00/1g

Yield:6228-73-5 100%

Reaction Conditions:

with ammonia in dichloromethane at 20; for 2 h;

Steps:

Intermediate 3: Synthesis of cvclopropanecarboxamide Ammonia was purged through a well-stirred solution of cyclopropane carbonyl chloride (1 g, 9.61 mmol) in dichloromethane (10 mL) for 2 hours at room temperature. Solvent was removed under vacuum, the residue was taken up in ethyl acetate and filtered The filtrate was concentrated to afford pure cyclopropanecarboxamide as a crystalline solid (0.81 g, 100%).¹H NMR (400 MHz, CHCI₃-cf): δ 5.63 - 5.91 (br. s, 2H), 1 .43 (m, 1 H), 0.98 (dd, J=4.42, 2.98 Hz, 2H), 0.79 (dd, J=7.91 , 2.95 Hz, 2H). MS: 85.91 (M+1 ).

References:

DAIICHI SANKYO COMPANY, LIMITED;VERMA, Ashwani, Kumar;NAGASWAMY, Kumaragurubaran;SHARMA, Lalima;GHOSH, Soma;KALE, Balkrishna, Ramchandra;MONDAL, Aniruddha;SRIVASTAVA, Punit, Kumar;DASTIDAR, Sunanda, Ghosh;MIYAUCHI, Rie;MURATA, Takeshi;ISHIZAKI, Masayuki;NAGAMOCHI, Masatoshi;IIMURA, Shin;MOMIN, Rijwan, Jaffer;WAGH, Pradip, Balu;PANSARE, Sonali, Nanasaheb;MARKAD, Pramod, Raosaheb;KHAIRNAR, Yogesh, Balasaheb WO2012/160464, 2012, A1 Location in patent:Page/Page column 59-60

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5500-21-0 Synthesis