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ChemicalBook CAS DataBase List L-ALANINE-1-13C
21764-56-7

L-ALANINE-1-13C synthesis

3synthesis methods
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
832 suppliers
$13.50/25G

201740-78-5 Synthesis
N-(TERT-BUTOXYCARBONYL)-L-ALANINE-1-13C

201740-78-5
18 suppliers
$45.00/10mg

-

Yield:201740-78-5 97%

Reaction Conditions:

Stage #1: di-tert-butyl dicarbonate;<1-13C>-L-alaninewith sodium hydrogencarbonate;sodium hydroxide in 1,4-dioxane at 20; for 28 h;
Stage #2: with dmap in 1,4-dioxane;water at 50; for 1 h;

References:

Hata, Ryunosuke;Nonaka, Hiroshi;Takakusagi, Yoichi;Ichikawa, Kazuhiro;Sando, Shinsuke [Angewandte Chemie - International Edition,2016,vol. 55,# 5,p. 1765 - 1768][Angew. Chem.,2016,vol. 128,# 5,p. 1797 - 1800,4] Location in patent:supporting information

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