ChemicalBook CAS DataBase List Ketoprofen

Ketoprofen synthesis

11synthesis methods

Product Name:Ketoprofen
CAS Number:22071-15-4
Molecular formula:C16H14O3
Molecular Weight:254.28

Ketoprofen, 2-(3-benzoyl)propionic acid (3.2.37), is synthesized from 3-methylbenzophenone, which undergoes bromination and forms 3-bromo-methylbenzophenone (3.2.33). The reduction of the resulting product by sodium cyanide gives 3-cyanomethylbenzophenone (3.2.34), which is reacted with the diethyl ester of carbonic acid in the presence of sodium ethoxide. The resulting cyanoacetic ester derivative (3.2.25) is alkylated by methyl iodide and the resulting product (3.2.36) undergoes acidic hydrolysis, forming ketoprofen (3.2.37) [104–106].

42872-30-0 Synthesis

42872-30-0
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$15.00/1g

22071-15-4
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$5.00/1g

Yield:22071-15-4 92.8%

Reaction Conditions:

with sulfuric acid for 7 h;Reflux;

Steps:

6 Example 6: Preparation of a compound of formula VII

Add a compound of formula VI (10g, 0.042mol) and an 80% sulfuric acid solution (10.3g, 0.084mol) to a 250ml reaction bottle, and start heating to reflux. After holding the reaction for 7 hours, take a sample and test. After the raw materials disappear, the temperature begins to fall. material. After stirring at 7 ° C for 1 hour, suction filtration, washing with a small amount of water, and drying, 10.6 g of a compound of formula VII was obtained, with an HPLC content of 94.6% and a yield of 92.8%.

References:

CN110857269,2020,A Location in patent:Paragraph 0193-0195

105-39-5 Synthesis